WEN-CHIH CHIANGSHUEI-LIONG LINYUNG-MING CHENKWAN-DUN WUTUN-JUN TSAI2021-01-122021-01-1220081320-5358https://www.scopus.com/inward/record.uri?eid=2-s2.0-40349116013&doi=10.1111%2fj.1440-1797.2008.00933.x&partnerID=40&md5=e7f6a8a1d68a3aecb6336de551e4808ehttps://scholars.lib.ntu.edu.tw/handle/123456789/540378Aim: This study was to evaluate the correlation of urinary kallikrein to renal function, proteinuria and urinary cytokines in chronic kidney disease patients in a longitudinal follow up. Method: We measured urinary kallikrein and cytokines in 50 patients who were followed up for 12 months. Results: Using regression model we found that the kallikrein excretion (estimated by log kallikrein/creatinine) was positively correlated to log estimated glomerular filtration rate in the beginning and the end of follow up (P = 0.049 and 0.006, respectively). No correlation existed between kallikrein excretion and proteinuria. The kallikrein excretion decreased after 12 months of follow up, which was also associated with the decrease of log estimated glomerular filtration rate. There was a significant positive correlation between the log urinary kallikrein and monocyte chemoattractant protein-1 (MCP-1) concentration (correlation coefficient = 0.277; P = 0.049). Urinary kallikrein excretion was also positively correlated with serum MCP-1 level (correlation coefficient = 0.431; P = 0.002). No correlation existed between urinary kallikrein and transforming growth factor β-1 or tumour necrosis factor-α concentration. Conclusion: Urinary kallikrein excretion is positively correlated to renal function, serum and urinary inflammatory mediator MCP-1 in chronic kidney disease patients. These findings indicate that urinary kallikrein excretion may reflect the change of renal function and kidney inflammatory status. ? 2008 The Authors.[SDGs]SDG3angiotensin 2 receptor antagonist; kallikrein; monocyte chemotactic protein 1; transforming growth factor beta1; tumor necrosis factor alpha; adult; aged; article; chronic kidney disease; clinical article; controlled study; correlational study; female; glomerulus filtration rate; human; kidney function; male; priority journal; proteinuria; urinary excretion; Angiotensin II Type 1 Receptor Blockers; Biological Markers; Chemokine CCL2; Cytokines; Female; Follow-Up Studies; Glomerular Filtration Rate; Humans; Inflammation Mediators; Kallikreins; Losartan; Male; Middle Aged; Nephritis; Proteinuria; Regression Analysis; Renal Insufficiency, Chronic; Time Factors; Transforming Growth Factor beta1; Treatment Outcome; Tumor Necrosis Factor-alphajournal article10.1111/j.1440-1797.2008.00933.x183157022-s2.0-40349116013