CHE-MING TENG2018-09-102018-09-102012http://www.scopus.com/inward/record.url?eid=2-s2.0-84863231760&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/368805Four new apigenin derivatives, 7-de-O-methylaciculatin (1), 8-C-β-d-boivinopyranosylapigenin (2), aciculatinone (3), and 4′-O-glucosylaciculatin (4), along with eight known compounds, apigenin-8-carbaldehyde (5), kaempferol, tricin, taxifolin, 6,7,4′- trihydroxyflavone, trans-oxyresveratrol, aciculatin, and luteolin-7-sulfate, were isolated from an ethanolic extract of Chrysopogon aciculatis. Their chemical structures were elucidated by spectroscopic methods. Among the known compounds, the natural occurrence of apigenin-8-carbaldehyde and luteolin-7-sulfate is demonstrated for the first time. Some of the isolates were evaluated for cytotoxic activity against human cancer cell lines including MCF-7, H460, HT-29, and CEM. ? 2012 The American Chemical Society and American Society of Pharmacognosy.[SDGs]SDG34' o glucosylaciculatin; 6,7,4' trihydroxyflavone; 7 de o methylaciculatin; 8 c beta dextro boivinopyranosylapigenin; aciculatin; aciculatinone; antineoplastic agent; apigenin 8 carbaldehyde; apigenin derivative; Chrysopogon aciculatis extract; kaempferol; luteolin 7 sulfate; plant extract; taxifolin; trans oxyresveratrol; tricin; unclassified drug; antineoplastic activity; article; chemical structure; Chrysopogon aciculatis; controlled study; cytotoxicity; drug isolation; human; human cell; medicinal plant; spectroscopy; Antineoplastic Agents, Phytogenic; Apigenin; Drug Screening Assays, Antitumor; Female; Flavonoids; HT29 Cells; Humans; Kaempferols; Molecular Structure; Poaceae; Taiwan; Chrysopogonjournal article10.1021/np2007796