2013-08-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/688003摘要：嵌段共聚物的自組裝微胞化行為一般發生於液態溶劑中，藉由分子量與溶劑的調控可形成多樣的結構，其中囊泡(vesicle)&#29234;最受重視的結構之一，因為其核心具備包覆藥物分子的能力，可應用於藥物的控制釋放。然而，在液態溶劑中因為藥物被大量稀釋，囊泡內部僅能包覆少許的藥物，且能直接在水溶液中形成囊泡的嵌段共聚物並不多見，一般所使用的有機溶劑具有毒性，這些因素皆限制了傳統囊泡的應用。本研究計畫主要目的在發展新的囊泡製備技術，讓囊泡核心部分能完整包覆藥物分子，且最後所形成囊泡不含有毒的溶劑。我們將利用嵌段共聚物與藥物分子之間的作用力，讓嵌段共聚物能直接在高溫熔融態或少量溶劑軟化的藥物分子中形成囊泡，這些囊泡的核心部分將佈滿藥物分子，且當溫度下降至室溫或溶劑揮發後，藥物分子結晶，囊泡結構依舊可以保留在固化的樣品中。這種囊泡可利用溶劑完整萃取出來形成內含藥物分子的奈米膠囊，奈米膠囊可更進一步分散於生物相容的溶劑或高分子介質中以進行藥物釋放的應用。我們將探討囊泡的形成機制以及其藥物釋放的行為與速率。<br> Abstract: Amphiphilic block copolymers self-assemble into a variety of structures, generally in liquid media, among which vesicles draw much attention due to their ability to encapsulate drug molecules to be used for controlled release applications. However, it has been shown that the encapsulation efficiency of vesicles is low for diluted drug molecules in liquid systems. Also, the liquid media where vesicles are formed generally involve toxic organic solvents. Their applications are thus limited. In this proposal, we aim to develop new routes to produce non-toxic block copolymer vesicles with high encapsulation capacity, that is, instead of liquid media, drug molecules which are crystalline solids at room temperature will be directly used as media for the formation of vesicles. The molecular mobility required for assembly process will be imparted by heating up the drug molecules into melt states or by the diffusion of proper solvent vapors into the drugs. By using this method, a great amount of drug molecules can be directly enclosed inside the cores of the block copolymer-based vesicles. The vesicles formed in these softened states can be retained in crystalline solids after samples are cooled down to room temperature or after the evaporation of the mediate solvents. Moreover, the drug-filled vesicles can be extracted in an intact form by proper solvents and can then be re-dispersed in desired solvents or in other polymer media for further applications. We will investigate the mechanisms that govern the formation of such vesicles as well as the control release of drugs.