2016-01-012024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/648342摘要：為提升國家競爭力，本計晝以推動整合型計晝進行研究之模式進行，規劃以集中發展五個關鍵領域和 三種應用技術為主。2008年依據2006年「幹細胞研發重點策略藍圖計晝」而提出發展重點，包含五 個關鍵領域：（1)幹細胞的分離，培養與分化技術、（2)幹細胞的表現機制與流程控制、（3)後生性 遺傳(epigenetic)調節與體細胞核核轉移的技術研發（4)動物移植模型、生醫奈米、與組織工程相關技 術的建置（5)「誘導式多能性幹細胞(iPS cells)」相關之分析研究，及三種應用技術：（1)異體移植模 型、（2)藥物研發及（3)細胞治療的試驗。接著在2010年幹細胞工作小組第二次會議討論出最新的 幹細胞研究方向：（1)胚胎幹細胞、（2)多潛能(特定組織)的間葉幹細胞、（3)成體幹細胞、（4)生 殖幹細胞、（5)重編程、分化及形態發生、（6)組織工程、（7)活體影像技術（電腦斷層磁振造影、 正子斷層掃描追蹤幹細胞）、（8)癌症幹細胞。本計晝目標為有效整合不同領域幹細胞研究相關的人力與資源，提升研究團隊水準，於2007年起推 動七件整合型幹細胞及再生醫學研究旗艦計晝，依據以上提出的重點，進行具國際競爭力核心領域的 研發。其後，於2011年10月至103年9月推動幹細胞及再生醫學前瞻計晝，在103年7月舉辦期末 成果發表會。103年辦理最新一期研究計晝的徵求工作，現期共推動四件整合型幹細胞及再生醫學前 瞻計晝，將於105年9月執行期滿。本計晝今年度將著重於規劃未來幹細胞及再生醫學研究方向、管 考計晝進度及品質、召開與產業界專業人士之座談會、協助推動國際合作計晝。<br> Abstract: The project aims to promote stem cell research in Taiwan by fully organizing domestic research experts and resources. To proper allocate research resources to achieve our mission, we will support five to six research groups in five key research topics. The proposed five research focuses are (1)The culture and differentiation of stem cell, (2) Mechanisms and pathways control of stem cells, (3) Epigenetic regulation and nuclear transfer (4) Animal model for transplantation, biomedical nanotechnology, and tissue engineering, and (5) Induced pluripotent stem cell (iPS). Three applied technologies with special emphases: (1) Xenotransplantation models, (2) Drug discovery and development, (3) Clinical trial on stem cell therapy.We also chose 8 important areas for future research: (1) embryonic stem cells, (2) pluripotent and mesenchymal stem cells in specific tissues, (3) adult stem cells, (4) germline stem cells, (5) reprogramming, differentiation and morphogenesis, (6) tissue engineering, (7) in vivo imaging techniques (MRI, CT applied on tracking stem cells), and (8) cancer stem cells.In order to integrate human resources and research facilities, we supported 7 Stem cell and Regenerative Medicine Flagship research programs from 2007 to September 2011. These research teams have achieved a remarkable progress. Started in October 2011, 5 Stem Cell and Regenerative Medicine Frontier Research Programs granted by MOST were launched. The latest research programs started in October 2014 and will end in September 2016.This year, the specific aims for this office are (1) to plan for the future research directions, (2) to inspect research performance and quality of the flagships every season, (3) to hold forum with industry professionals in the field, and (4) to assistant potential international cooperation with leading research groups in the world.幹細胞再生醫學胚胎幹細胞腫瘤幹細胞誘導性多能幹細胞Stem cellRegenerative medicineEmbryonic stem cellCancer stem cellInduced pluripotent stem cell (iPS)