新型奈米矽片及高分子複合膜之製備及其抗菌與生醫應用

2007-08-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/685734摘要：傳統技術製造奈米複合材料，將層狀黏土改質為不規則脫層型黏土需經兩個步驟：利用界面活性劑改質黏土，再與高分子進行混摻。近年 來計畫總主持人已開發一系列高分子型界面活性劑用於改質層狀黏土，所開發之界面活性劑利用離子交換方式，只需一個步驟就可脫層黏土；藉由此高分子型界面活性劑將多層狀黏土脫層為奈米矽片，其微觀結構約為100×100×1 nm3 薄片狀，每一片皆獨立存在，且不互相堆疊與吸附，具有高電荷，能穩定分散於水溶液與有機溶液。綜觀各國期刊與世界專利，目前無相似性的奈米矽片材料。本計畫擬對此新穎無機奈 米矽片，進一步以親水或疏水性高分子(聚乙烯醇(polyethylene glycol)、脂肪胺(fatty amine)、poly(vinylalcohol)、EVOH、polyvinylpyrrolidone、 polyvinylpyridine、SMA)等修飾延伸出具操縱親水或親油性之矽片/有機複合物奈米材料；此三系列奈米材料均具有高分散性，可呈溶液態，並在高濃度下可形成凝膠，具流變特性，且均可與生醫材料混摻製成薄膜材料。此外它們還具有自組裝之特性，可各自組裝成一級、二級甚至三級結構。由於這些奈米材料的高離子負電荷性、特殊幾何特性與有機親和性等，我們將探討此新穎奈米材料製成薄膜態後，在抗微生物與抑制病菌機制方面的探討與其生<br> Abstract: Conventionally, the naturally-occurring clays have been widely utilized as nanocomposites, absorbents, catalysts, fillers for plastics, etc., but seldom for antimicrobial or biomedical applications. Recently, our research group has developed a direct process of using polyamine surfactants to exfoliate the layered silicate clay into random silicate platelets (NSP). The NSP material is unique in several aspects. It can be purified and isolated from water suspension and can be in gel form. The NSP is comprised of platelet-like silicate structure with an average dimension of 100×100×1 nm3 (high aspect-ratio) and 20,000 ion charges on each platelet (having intensive attracting force). The unique structure has strong tendency for interacting with polar organic polymers, metal ions and ionic charged biomaterials. . Preliminary results have shown they are effective for inhibiting the bacterial growth and DNA duplication. The NSP can be converted into different forms, such as solution, gel and solid film. Hence their applications can be diversified. In this proposal, we aim at further tailoring their hydrophilic and hydrophobic properties (by complexing with hydrophilic polymers such as polyethylene glycol, fatty amine, polyvinylpyrrolidone, polyvinylpyridine, EVOH, PVA and SMA and derivatives), and screening their potential biomedical applications. With various forms of the materials, applications such as antimicrobial for different areas, and studies on the mechanism will be investigated. The project will be tuned into interdisciplinary research between polymer materials, inorganic nanoparticles and biomedical applications, and expected to have fruitful results.界面活性劑&#63756米矽片天然黏土生醫應用surfactantnanosilicate plateletssmectite claysbiomedical新型奈米矽片及高分子複合膜之製備及其抗菌與生醫應用