Lin, W.-Y.W.-Y.LinLu, Y.Y.LuChen, B.-W.B.-W.ChenHuang, C.-Y.C.-Y.HuangSu, J.-H.J.-H.SuWen, Z.-H.Z.-H.WenCHANG-FENG DAIKuo, Y.-H.Y.-H.KuoSheu, J.-H.J.-H.Sheu2018-09-102018-09-102012http://www.scopus.com/inward/record.url?eid=2-s2.0-84859566922&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/370873Three new cembranoids, sarcocrassocolides M-O (1-3), have been isolated from the soft coral Sarcophyton crassocaule . The structures of the metabolites were determined by extensive spectroscopic analysis. Compounds 1-3 were shown to exhibit moderate cytotoxicity toward a limited panel of cancer cell lines and display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein. ? 2012 by the authors; licensee MDPI.Anti-inflammatory activity; Cytotoxic activity; Sarcophyton crassocaule; Soft coral[SDGs]SDG3antiinflammatory agent; cembranoid; cyclooxygenase 2; cytotoxic agent; drug metabolite; inducible nitric oxide synthase; lipopolysaccharide; mitomycin C; Sarcocrassocolide M; Sarcocrassocolide N; Sarcocrassocolide O; unclassified drug; antiinflammatory activity; article; cancer cell culture; concentration response; controlled study; coral; drug cytotoxicity; drug determination; drug effect; drug isolation; drug structure; enzyme inhibition; heteronuclear multiple bond correlation; heteronuclear multiple quantum coherence; human; human cell; macrophage; nonhuman; nuclear Overhauser effect; photon correlation spectroscopy; protein expression; Sarcophyton crassocaule; stereochemistry; Taiwan; upregulation; Alcyonacea; Sarcophyton crassocaulejournal article10.3390/md100306172-s2.0-84859566922WOS:000302136700008