2015-06-022024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/681877摘要：臺灣近來生活素質的提昇以及飲食習慣的西化，肥胖已經成為日益嚴重的健康問題。因肥胖而導致的疾病相當的多，如糖尿病、高血壓、高血脂症、心臟病、腦中風、退化性關節炎、脂肪肝、癌症等等，都和肥胖有極密切的關聯。飲茶養生的觀念流傳已久且被廣泛認同，主要為其富含多酚類化合物如兒茶素、茶紅素、類黃酮、酚酸與花青素等，且被提出具有多種生理功效。在許多研究報告中已證實茶內所含之多酚類化合物在&#64025;經退化、心血管疾病、慢性肝炎、腫瘤形成等，&#64038;具有&#63868;好的預防及抑制效果，因而賦予其在預防或對抗慢性疾病的研究潛力。因此，本委辦計畫將以動物模式評估並比較茶葉經茶蠶消化代謝後其蠶砂是否更具生理活性，並探討其在預防肥胖、脂肪肝發展與高血壓的功效與調節機制之特性，並期望此計畫之研究成果能更進一步了解茶蠶砂之功能性繼而作為未來應用在健字號產品開發之基礎。<br> Abstract: Due to the improved living quality and westernized eating habits, obesity has become a growing health problem. Many diseases including diabetes, hypertension, high cholesterol, heart disease, stroke, osteoarthritis, fatty liver, cancer, and many more, had been closely associated with obesity. Drinking tea as part of the dietary regime has long been widely recognized as an effective way to maintain optimum health. Varieties of physiological benefits have been documented from consumption of tea phenolics including catechins, theaflavins, flavonoids, phenolic acidsanthocyanins, and etc. Diseases, such as neuro-degeneration, cardiovascular disease, chronic hepatitis, and tumoregenesis, have been successfully prevented or inhibited by drinking tea rich in phenolic compounds. Therefore, present projectaim to further explore whether tea polyphenol after silkworm faeces will have better ability to inhibit obesity, hypertension, and fatty liver development using animal models. Through comparing with the intact tea polyphenol, this study will evaluate the efficacy and underlying mechanism of silkworm sand when exerting the biological functionalities. The results of this research projectwill help to better understand the function of tea silkworm sand and use it as reference for the development of future health product.肥胖兒茶素高血壓脂肪肝茶蠶砂obesitycatechinshypertensionfatty liversilkworm faeces