趙福杉2006-07-262018-06-292006-07-262018-06-292005-10-31http://ntur.lib.ntu.edu.tw//handle/246246/22393本計畫以功能性影像的方法來量測大腦 神經活化時相關生理反應的時間及空間分佈 情形。我們發現此種實驗模型在基礎神經科學 研究上提供了相當有價值的訊息。本研究使用 正子電腦斷層掃描與功能性磁振造影分別量 測神經活化時大腦對於葡萄糖的代謝以及血 氧濃度的變化。實驗結果不僅提供了大鼠後跂 及尾部在痛覺刺激時，大腦體感覺拓譜圖及其 動態反應，也使我們發現此分佈與電生理方法 所量測到結果大致吻合。The techniques of functional imaging were used to provide 3D spatial-temporal mapping of nociceptive responses during specific neural activation in brain. We find that the results could provide invaluable information for basic neuroscience research. For image experiments, we do in vivo brain mapping studies with 18F-FDG (Fluorodeoxyglucose) PET (Positron Emission Tomography) to measure relative cerebral metabolic rate of glucose (rCMRglc) and BOLD (Blood Oxygenation Level Dependent) fMRI (Functional Magnetic Resonance Imaging) to measure hemodynamic response. The results not only show the global somatotopic organization of noxious stimulation on hindquarters in rats, but also find that the activated positions were well correlated with electrophysiological experiments.application/pdf759526 bytesapplication/pdfzh-TW國立臺灣大學醫學工程學研究所微型正子電腦斷層掃描功能性磁振 造影大腦皮質視丘福馬林大鼠microPETfMRIcerebral cortexthalamusformalinratreporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/22393/1/932213E002066.pdf