SHIH-JUNG CHENGSANG-HENG KOKJANG-JAER LEEYEN-PING KUOCheng S.-L.Huang Y.-L.HSIN-MING CHENHAO-HUENG CHANGCHUN-PIN CHIANG2021-07-052021-07-0520121043-3074https://www.scopus.com/inward/record.uri?eid=2-s2.0-84864981889&doi=10.1002%2fhed.21923&partnerID=40&md5=2e1886b4640e9995e718d3648f754b7ahttps://scholars.lib.ntu.edu.tw/handle/123456789/569164Background Src protein overexpression correlates with progression and prognosis of a variety of human cancers. Methods This study used immunohistochemistry to examine the expression of Src protein in 93 specimens of oral squamous cell carcinoma (OSCC). Results We found a significant association of high expression of Src protein (labeling indices >50%) with larger tumor size (p =.017), positive lymph node metastasis (p =.030), more advanced clinical stages (p =.007), and recurrence (p <.001) of OSCC. High expression of Src protein was identified as an independent unfavorable prognosis factor by multivariate Cox regression analysis. The Kaplan-Meier curve showed that patients with OSCC with high expression of Src protein had a significantly poorer cumulative survival than those with low expression of Src protein (log-rank test, p =.00267). Conclusion The expression of Src protein is significantly associated with the progression, recurrence, and prognosis of OSCCs in Taiwan. ? 2011 Wiley Periodicals, Inc.[SDGs]SDG1[SDGs]SDG3membrane protein; Src protein; tumor marker; unclassified drug; advanced cancer; article; cancer growth; cancer recurrence; cancer size; cancer survival; controlled study; disease association; disease marker; female; human; human tissue; lymph node metastasis; major clinical study; male; mouth squamous cell carcinoma; priority journal; prognosis; protein expression; Taiwan; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Disease Progression; Female; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Male; Middle Aged; Mouth Neoplasms; Prognosis; Proteomics; Recurrence; src-Family Kinases; Taiwan; Tumor Markers, BiologicalSignificant association of SRC protein expression with the progression, recurrence, and prognosis of oral squamous cell carcinoma in Taiwanjournal article10.1002/hed.21923220528392-s2.0-84864981889