Synthesis of Anti-Microtubule N-(2-Arylindol-7-yl)-benzenesulfonamide Derivatives and Their Antitumor Mechanisms

Chiou, Chun-TangChun-TangChiouChen, Grace ShiahuyGrace ShiahuyChenChen, Meng-LingMeng-LingChenLi, HuomingHuomingLiShi, LeiLeiShiHuang, Xiang-HongXiang-HongHuangDai, Wei-MingWei-MingDaiChern, Ji-WangJi-WangChern2012-10-192018-07-062012-10-192018-07-062010http://ntur.lib.ntu.edu.tw//handle/246246/242993Breaking the cycle: A series of N-(2-arylindol-7-yl)benzenesulfonamide derivatives were prepared. Among them, compound 2 showed promising antiproliferative activity against hormone-resistant prostate cancer PC-3 cells, induced G2/M-phase arrest, and induced apoptosis through a caspase-dependent pathway. (Chemical Equation Presented). ? 2010 wiley-vch verlag gmbh & co. KGaA.en-USAntimitotic agents; Apoptosis; Benzenesulfonamides; Cytotoxicity; Microtubules[SDGs]SDG3(2 phenylindol 7 yl) 4 toluenesulfonamide; antineoplastic agent; benzenesulfonamide derivative; n (2 phenylindol 7 yl) 4 methoxybenzenesulfonamide; n (3 chloro 2 phenylindol 7 yl) 4 methoxybenzenesulfonamide; n (3 formyl 2 phenylindol 7 yl) 4 methoxybenzenesulfonamide; n (3 hydroxymethyl 2 phenylindol 7 yl) 4 methoxybenzenesulfonamide; n (3 piperidinomethyl 2 phenylindol 7 yl) 4 methoxybenzenesulfonamide; n [2 (4' biphenyl)indol 7 yl] 4 methoxybenzenesulfonamide; n [2 (4' methoxyphenyl)indol 7 yl] 4 methoxybenzenesulfonamide; n [2 (4' tolyl)indol 7 yl] 4 methoxybenzenesulfonamide; n [2 [4' (4'' methoxybenzenesulfonamido)phenyl]indol 7 yl] 4 methoxybenzenesulfonamide; n [3 (4 morpholino)methyl 2 phenylindol 7 yl] 4 methoxybenzenesulfonamide; unclassified drug; antineoplastic activity; article; cancer cell culture; cell cycle arrest; cell cycle G2 phase; cell cycle M phase; controlled study; drug mechanism; drug potency; drug synthesis; human; human cell; IC 50; microtubule assembly; mitosis; priority journal; structure activity relation; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Drug Screening Assays, Antitumor; G2 Phase; Humans; Indoles; Male; Microtubules; Prostatic Neoplasms; Structure-Activity Relationship; Sulfonamides; Tubulin ModulatorsSynthesis of Anti-Microtubule N-(2-Arylindol-7-yl)-benzenesulfonamide Derivatives and Their Antitumor Mechanismsjournal article10.1002/cmdc.201000228http://ntur.lib.ntu.edu.tw/bitstream/246246/242993/-1/99.pdf