ZEI-SHUNG HUANGTIEN-SHANG HUANGTZY-HAW WUMING-FONG CHENHsu C.-S.JIA-HORNG KAO2020-06-032020-06-0320100815-9319https://www.scopus.com/inward/record.uri?eid=2-s2.0-77954892255&doi=10.1111%2fj.1440-1746.2010.06268.x&partnerID=40&md5=ab3432dfb0fc518cb354279700713ab4https://scholars.lib.ntu.edu.tw/handle/123456789/496807Background and Aim: Chronic hepatitis C virus infection has been known to increase the risk of diabetes. Whether this association holds true for chronic hepatitis B virus (HBV) infection remains unclear. We thus conducted this study to investigate the influence of asymptomatic chronic HBV infection on the incidence of diabetes in a longitudinal cohort. Methods: A total of 1233 adults who received health examinations in 1997-1998 and in 2000-2001 were enrolled. Among them, 483 subjects who received a third health examination in 2006-2008 were further sampled. The prevalence and incidence of diabetes between asymptomatic HBV carriers and non-HBV controls were compared using the χ2-test and logistic regression. Results: In 1997-1998, the prevalence rates of diabetes (9.49 and 12.0%) and glucose intolerance (28.5 and 25.4%) in HBV carriers and non-HBV controls were comparable (P > 0.05). There was no significant correlation between asymptomatic HBV infection and the presence of diabetes in subjects examined in 1997-1998, 2000-2001, or 2006-2008 when adjusted for age, gender, and body mass index (P > 0.05). In 296 non-diabetic subjects during 1997-1998, the ten-year incidence of diabetes/glucose intolerance was similar between HBV carriers and non-HBV controls (40.0 and 38.7%, P > 0.05). Moreover, no significant correlation was found between asymptomatic HBV infection and the incidence of diabetes/glucose intolerance in 2006-2008 (P = 0.775). Conclusions: Compared to non-HBV controls, subjects with asymptomatic chronic HBV infection do not have an increased risk of diabetes, and thus HBV itself is not pro-diabetic. ? 2010 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.[SDGs]SDG3adult; article; body mass; cohort analysis; controlled study; demography; diabetes mellitus; female; glucose intolerance; hepatitis C; Hepatitis C virus; human; incidence; longitudinal study; major clinical study; male; medical examination; observational study; prevalence; priority journal; risk factor; Taiwan; virus carrierjournal article10.1111/j.1440-1746.2010.06268.x2-s2.0-77954892255