2012-08-012024-05-14https://scholars.lib.ntu.edu.tw/handle/123456789/657846摘要：長期低濃度多重金屬暴露是現今環境污染暴露的主要形式之一，但國內目前尚未有較完整的學齡前兒童金屬暴露的研究。本三年期研究計畫將調查學齡前兒童金屬濃度分佈、潛在影響因素與可能的健康影響。研究對象為已收案的研究世代，是由先經分層隨機選取之區、市、鎮、鄉行政區域內的934名幼稚園學齡前兒童所組成。以問卷訪視獲取個人、家庭及環境暴露資料，利用感應偶合電漿質譜儀分析血中多重金屬濃度，並分析與人內體金屬吸收代謝相關之基因多型性。第一年計畫將建立臺灣地區學齡前兒童血中鉛、汞、砷、鋅、鎘、錳、鋅、銅等之濃度背景值，並探討其影響因素，以及釐清IgE總過敏原與各種血中金屬濃度之相關性。第二年計畫將分析學齡前兒童血中金屬濃度與人體內金屬代謝相關之基因多型性的相關性，以結構方程式模型評估低濃度多重金屬暴露、金屬代謝相關之基因多型性，以及環境影響因素共同對學齡前兒童注意力缺陷的影響。第三年計畫建立學齡前兒童血中鎵、鍺、銦、鉑、錸、釕、鈦、鉈、鉬等特殊金屬濃度背景值，探討學齡前兒童血中特殊金屬濃度與新科技工業及交通污染源之關係。研究成果將可作為擬定國內環境金屬暴露防治工作策略的根據，並提供學術工作進一步探討金屬暴露易感受性研究的基礎。<br> Abstract: Chronic multiple metal exposure is one of the major types of environmental pollutantexposure. However, there is no comprehensive survey on the preschool children’s metalexposure in Taiwan. This three-year study will study on the distributions of blood metallevels of the preschool children, critical factors for exposure to metals, and the potentialadverse health effects. Total 934 preschool children were previously recruited fromkindergartens located in the randomly selected townships or city districts based on astratified sampling strategy. Information on demographics and environmental exposurefactors were collected through questionnaire administration for each study subject. Metallevels in blood samples of the preschool children will be determined with inductive coupledplasma, while polymorphism of the metal metabolism related gene will also be analyzed inthe present study. In the first study year, the norms of lead, mercury, arsenic, zinc, cadmium,manganese, zinc, and copper levels in blood of the preschool children will first beestablished, and the relevant exposure factors will also be elaborated. In addition, theassociation between total immunoglobulin E and the multiple metal levels in blood will beexamined as well. In the second study year, the study will first explore the relationshipsbetween the multiple metal levels in blood of the preschool children and the polymorphismof the metal metabolism related genes. Meanwhile, a structure equation model will beapplied to comprehensively evaluate the effects of chronic multiple metal exposure,polymorphism of the metal metabolism related genes, and environmental exposure factorson the attention deficit of the preschool children. In the third study year, the norms of specialmetals, including gallium, germanium, indium, platinum, rhenium, ruthenium, titanium,thallium and molybdenum, in blood of the preschool children will first be established.Meanwhile, this part of study will also explore the relationship between the levels of theseconcerned special metals in blood of the preschool children and the emission sources amongthe new technology industry and traffic transportation. Research products of the presentstudy will benefit the construction of an appropriate strategy for environmental metalexposure prevention in Taiwan, and provide necessary fundamentals for the continuousacademic research on human susceptibility to metal exposure.