Contribution of the APOE Genotype to Cognitive Impairment in Individuals With NOTCH3 Cysteine-Altering Variants

YU-WEN CHENGLiao, Yi-ChuYi-ChuLiaoCHIH-HAO CHENChung, Chih-PingChih-PingChungFann, Cathy S JCathy S JFannChang, Chien-ChingChien-ChingChangLee, Yi-ChungYi-ChungLeeSUNG-CHUN TANG2023-12-122023-12-122023-11-212047-9980https://scholars.lib.ntu.edu.tw/handle/123456789/637713Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most prevalent monogenic cerebral small-vessel disease. Phenotype variability in CADASIL suggests the possible role of genetic modifiers. We aimed to investigate the contributions of the APOE genotype and Neurogenic locus notch homolog protein 3 (NOTCH3) variant position to cognitive impairment associated with CADASIL.enAPOE; CADASIL; NOTCH3; cerebral small‐vessel disease; vascular cognitive impairment[SDGs]SDG3[SDGs]SDG4Contribution of the APOE Genotype to Cognitive Impairment in Individuals With NOTCH3 Cysteine-Altering Variantsjournal article10.1161/JAHA.123.032689379822142-s2.0-85178389024https://api.elsevier.com/content/abstract/scopus_id/85178389024