YEN-HUNG LINPao K.-Y.VIN-CENT WULin Y.-L.Chien Y.-F.CHI-SHENG HUNGChen Y.-J.Tsai I.-J.I-JUNG TSAIGau C.-S.KWAN-DUN WUJUEY-JEN HWANG2020-09-282020-09-2820070009-9120https://www.scopus.com/inward/record.uri?eid=2-s2.0-33846229703&doi=10.1016%2fj.clinbiochem.2006.11.010&partnerID=40&md5=042790dc51608f24eab155045033fc8ahttps://scholars.lib.ntu.edu.tw/handle/123456789/515202Objectives: To examine the relation of estimated creatinine clearance (eCrCl) and plasma total homocysteine (tHcy) in hypertensive patients with a normal serum creatinine level. Design and methods: A total of 137 hypertensive patients (mean age 66.6?years, 69?men) with serum creatinine level ? 1.5?mg/dL gave 10-h fasting blood samples for measurement of tHcy, serum folic acid, and serum vitamin B12. Results: 95 patients fell into a chronic renal insufficiency (CRI) group (eCrCl ? 60?mL/min/1.73?m2) and 42 into a normal renal function (NRF) group (eCrCl > 60?mL/min/1.73?m2). The CRI group was older (p < 0.001), had higher tHcy (p < 0.001), higher serum urea nitrogen (p < 0.001), higher serum creatinine (p < 0.001), lower eCrCl (p < 0.001), and lower diastolic blood pressure (p = 0.001). In univariate analysis, eCrCl had the strongest correlation with tHcy (r = - 0.453, p < 0.001). Significant correlations, ranging in decreasing order from r = - 0.418, p < 0.001 to r = - 0.170, p = 0.047, were also noted between tHcy and twelve other variables. In multivariate analysis, only eCrCl (p < 0.001), usage of fibrate (p < 0.001), serum level of vitamin B12 (p = 0.002), serum level of folic acid (p = 0.009), and smoking (p = 0.027) were independent predictors of tHcy. Conclusion: eCrCl is a strong independent predictor of tHcy in hypertensive patients with normal serum creatinine. ? 2006 The Canadian Society of Clinical Chemists.[SDGs]SDG3creatinine; cyanocobalamin; fibric acid derivative; folic acid; homocysteine; adult; aged; article; blood sampling; chronic kidney failure; controlled study; correlation analysis; creatinine blood level; creatinine clearance; diastolic blood pressure; female; folic acid blood level; human; hypertension; kidney function; major clinical study; male; multivariate analysis; predictor variable; priority journal; smoking; univariate analysis; urea nitrogen blood level; vitamin blood level; Aged; Biological Markers; Creatinine; Female; Homocysteine; Humans; Hypertension; Kidney Diseases; Malejournal article10.1016/j.clinbiochem.2006.11.010172228112-s2.0-33846229703