RONG-SEN YANG2021-05-312021-05-3120051016-3190https://www.scopus.com/inward/record.uri?eid=2-s2.0-29944445689&partnerID=40&md5=d92c7e7da90dc751512f38366f92db39https://scholars.lib.ntu.edu.tw/handle/123456789/563787Neoadjuvant chemotherapy, modern imaging analyses, and developments in surgical techniques in recent decades have enabled limb salvage surgery to provide well-functioning, tumor-free, painless limbs through excision of the tumor with an adequate margin and proper reconstruction. With proper selection, patients are expected to have mostly intact body balance, a simple rehabilitation process, and an intact body image, but not at the expense of local recurrence and survival. Currently the indications of such a limb salvage procedure have been expanded to other non-malignant tumorous conditions in addition to malignant juxta-articular bone tumors in the extremities. Wide resection of a tumor can result in massive bone and soft-tissue defects. Currently, many options for reconstruction with limb salvage procedures are available, including resection arthrodesis, various bone graft techniques (vascularized or conventional autografts, allografts, or allograft/ endoprosthesis composites), Ilizarov leg lengthening, rotationplasty, reconstruction with custom-made oncological endoprostheses, etc. These have resulted in expected successes, while simultaneously producing biological or prosthesis-related complications due to their unique advantages and disadvantages. The choice of an option requires careful individual considerations, including imaging radiological staging, pathological staging, and the clinical status.Bone graft; Complications; Endoprosthetic reconstruction; Limb salvage operation; Modular oncological endoprosthesis[SDGs]SDG3allograft; arthrodesis; autograft; balance disorder; bone graft; bone remodeling; bone tumor; cancer chemotherapy; cancer recurrence; cancer staging; cancer surgery; cancer survival; clinical trial; diagnostic imaging; endoprosthesis; human; Ilizarov technique; leg lengthening; limb salvage; patient selection; postoperative complication; review; rotation; soft tissue defect; staging; systematic review; treatment outcomereview2-s2.0-29944445689