Yung-Chi LeeYi-Chen ChenChun-Fu WuWoo-Jin Yoo2024-11-112024-11-112024-10-2215237060https://www.scopus.com/record/display.uri?eid=2-s2.0-85207316270&origin=resultslisthttps://scholars.lib.ntu.edu.tw/handle/123456789/722943A two-step procedure, combining a SmI2-mediated transannular pinacol coupling reaction with an acid-catalyzed pinacol rearrangement process, was employed to prepare a diverse range of 1-substituted bicyclo[2.1.1]hexan-5-ones from cyclobutanedione derivatives. To underscore the significance of these bicyclic ketones in drug synthesis, an sp3-rich analog of nitazoxanide, a well-known antiparasitic and antiviral agent, was synthesized.truejournal article10.1021/acs.orglett.4c035412-s2.0-85207316270