Chou C.H.Kang K.T.WEN-CHIN WENGPEI-LIN LEEWEI-CHUNG HSU2020-07-202020-07-2020140307-0565https://www.scopus.com/inward/record.uri?eid=2-s2.0-84891830514&doi=10.1038%2fijo.2013.184&partnerID=40&md5=61dcb24fcbe1a0c179c907a0c9ad1174https://scholars.lib.ntu.edu.tw/handle/123456789/510207Objectives:In contrast to obstructive sleep apnea (OSA), central sleep apnea (CSA) in obese children has received lesser attention. As pediatric CSA is more prevalent than expected and adversely impacts health, this study aims to elucidate the major factors associated with central apnea index (CAI) and compare CSA between obese and non-obese children.Methods:Retrospective analysis was performed in a tertiary referral medical center. Children with sleep-disordered breathing (SDB) ranging from 2-18 years old were enrolled. All participants completed history taking, otolaryngological examination and overnight polysomnography. CSA was defined as having CAI exceeding 1 h-1. CAI and the prevalence of CSA were analyzed in children of different age groups, weight statuses and adenotonsillar sizes.Results:A total of 487 cases were included. The prevalence of CSA was 13.3% (65/487). CAI was negatively correlated with age (r=-0.32, P<0.001). Obese children had a significantly lower CAI than that of non-obese ones (0.20±0.36 vs 0.48±0.82 h-1, P<0.001). Multiple linear regression analysis demonstrated a relationship between CAI, age and obesity as 'CAI=0.883-0.055 × Age-0.22 × (Obesity)'.Conclusions:In children with SDB, younger ones have a significantly higher CAI than older ones. Additionally, obese children had a lower CAI than non-obese ones. ? 2014 Macmillan Publishers Limited.[SDGs]SDG3adenotonsillar hypertrophy; adolescent; anamnesis; apnea index; article; central sleep apnea syndrome; child; childhood obesity; clinical assessment; female; groups by age; human; major clinical study; male; oxygen desaturation; polysomnography; preschool child; priority journal; school child; sleep disordered breathing; sleep parameters; Adenoids; Adolescent; Analysis of Variance; Child; Child, Preschool; Female; Humans; Male; Palatine Tonsil; Pediatric Obesity; Polysomnography; Prevalence; Retrospective Studies; Sleep Apnea Syndromes; Sleep Apnea, Central; Tonsillectomyjournal article10.1038/ijo.2013.184240481432-s2.0-84891830514