YU-WEN TIENCHIH-YUAN LEECHUN-CHIEH HUANGREY-HENG HUPO-HUANG LEE2022-01-072022-01-0720101068-9265https://www.scopus.com/inward/record.uri?eid=2-s2.0-74649085457&doi=10.1245%2fs10434-009-0761-5&partnerID=40&md5=9d79b1ee8b0e988b66ea2ae40aae9d24https://scholars.lib.ntu.edu.tw/handle/123456789/591863Background: Duodenal gastrointestinal stromal tumors (GISTs) represent a unique dilemma with varied surgical treatment options. However, the impact of operative methods on disease recurrence has never been addressed. Methods: We retrospectively reviewed the medical records of all patients with duodenal GISTs treated at our hospital from January 2001 to December 2008. Results: Of the 25 patients included for analysis, 9 had pancreaticoduodenectomy (PD) and 16 had limited operation. Comparison of clinicopathological data between tumors treated by PD and by limited operation showed no significant differences in patient age, sex, symptoms, location of tumor, tumor grade, immunohistochemical staining pattern, or complications after surgery. However, patients with tumors >5 cm (P = 0.005) or not diagnosed as GISTs before surgery (P = 0.004) were significantly more frequently treated by PD. In multivariable analysis, the only significant predictor for disease recurrence was high-risk duodenal GISTs. Conclusions: Based on the fact that type of operation was not correlated to operative risk and disease recurrence, limited operation rather than PD should be attempted for duodenal GIST without involvement of papilla of Vater to preserve more pancreas parenchyma, duodenum, and common bile duct. ? 2009 Society of Surgical Oncology.[SDGs]SDG3abdominal mass; abdominal pain; adult; aged; article; cancer patient; cancer recurrence; cancer surgery; clinical article; controlled study; duodenum; female; gastrointestinal hemorrhage; gastrointestinal stromal tumor; high risk patient; hospital; human; immunohistochemistry; male; medical record; pancreaticoduodenectomy; retrospective study; staining; surgical risk; Adult; Aged; Duodenal Neoplasms; Female; Follow-Up Studies; Gastrointestinal Stromal Tumors; Humans; Male; Medical Records; Middle Aged; Neoplasm Recurrence, Local; Pancreaticoduodenectomy; Prognosis; Retrospective Studies; Survival Rate; Treatment Outcomejournal article10.1245/s10434-009-0761-5198419812-s2.0-74649085457