Cheng C.-H.Tsau Y.-K.I-JUNG TSAI2020-12-212020-12-2120050272-6386https://www.scopus.com/inward/record.uri?eid=2-s2.0-27144438537&doi=10.1053%2fj.ajkd.2005.07.033&partnerID=40&md5=0fedf24b08897d005d6e9df216f7a829https://scholars.lib.ntu.edu.tw/handle/123456789/530119Background: We previously showed a positive correlation between nephromegaly and plasma hepatocyte growth factor (HGF)/transforming growth factor β1 (TGF-β1) ratio in children with biliary atresia. The purpose of this study is to examine the possible reversibility of nephromegaly in patients with biliary atresia. Methods: We evaluated kidney volume in 13 patients with biliary atresia before and after liver transplantation, 6 patients with hepatoblastoma, and 26 healthy children. Plasma HGF and TGF-β1 levels were determined for all children. Results: We noted significant nephromegaly in children with biliary atresia before liver transplantation compared with healthy children and children after liver transplantation (P < 0.001 and P = 0.006 for intercepts, P = 0.064 and P = 0.753 for slopes by analysis of covariance, respectively). The highest plasma HGF levels and HGF/TGF-β1 ratios and the lowest TGF-β1 concentrations were found in children with biliary atresia before liver transplantation (P < 0.001). No statistically significant nephromegaly was observed in children with biliary atresia after liver transplantation or those with hepatoblastoma despite the presence of a mildly increased plasma HGF level and HGF/TGF-β1 ratio. Plasma HGF/TGF-β1 ratio correlated positively with degree of nephromegaly in all patients (r = 0.717; P < 0.001). Conclusion: Our data suggest that liver transplantation reverses the nephromegaly present in children with biliary atresia and that plasma HGF/TGF-β1 ratio may be associated with the development of nephromegaly in patients with biliary atresia. ? 2005 by the National Kidney Foundation, Inc.Biliary atresia; Hepatoblastoma; Hepatocyte growth factor; Liver transplantation; Nephromegaly; Transforming growth factor β1[SDGs]SDG3scatter factor; transforming growth factor beta1; article; bile duct atresia; child; clinical article; controlled study; correlation analysis; disease association; hepatoblastoma; human; infant; kidney hypertrophy; liver transplantation; statistical analysis; statistical significance; Biliary Atresia; Biological Markers; Child; Child, Preschool; Female; Hepatoblastoma; Hepatocyte Growth Factor; Humans; Infant; Kidney; Liver Neoplasms; Liver Transplantation; Male; Organ Size; Postoperative Period; Transforming Growth Factor beta; Transforming Growth Factor beta1journal article10.1053/j.ajkd.2005.07.033162537222-s2.0-27144438537