2017-05-012024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/649046摘要：腸病毒感染為幼兒常見的疾病，而感染腸病毒71型最容易導致嚴重腦幹炎等併發症而致死或有後遺症，尤以5歲以下的幼兒為高危險群。2005-2016年監測資料顯示，國內腸病毒重症個案於2005、2008及2012年個案數較多，每3-4年似有一波較多重症個案的流行，且多與當年社區檢出較多EV71相關。2016年EV71檢出情形雖較過去三年為多，且主要出現在花蓮縣，但並未出現大流行，亦無重症個案增加之情形。距上一次(2012年)EV71流行已超過四年，為評估EV71爆發流行之風險，亟需了解重症高風險族群及高傳播族群EV71血清流行病學情形，以為未來流行評估之參考及日後腸病毒71型疫苗政策訂定之依據。我們擬於北部 (台北市/新北市)、中南部 (雲林縣/高雄) 、 東部 (花蓮縣/台東縣) ，進行不同地區及城鄉間高危險群(年齡分層為0-1歲、1-2歲、2-3歲及3-6歲)及高傳播者(年齡分層為小學7-12歲、中學13-15歲及育齡婦女)之問卷調查及腸病毒71型血清流行病，進而估計腸病毒71型在各年齡層的感染率。這對於腸病毒71型在台灣不同年紀及各區域感染的情況、城市與鄉村的差別、性別差異及預測未來腸病毒71型可能的流行情況，將有很大的幫助。上述結果，亦可為日後腸病毒71型疫苗政策訂定之依據。<br> Abstract: Enterovirus infection is very common in young children, and enterovirus 71 infection is most likely to lead to serious complications such as brainstem encephalitis, resulting in death or sequelae, especially in children under 5 years of age. Enterovirus monitoring data from 2005 - 2016 by Taiwan CDC show that there were more domestic severe enterovirus cases in 2005,2008 and 2012, so there seems to be a wave of more serious enteroivrus cases every 3 to 4 years, which is related to more EV71 detected in the community. EV71 in 2016, although more than the past three years and mainly in Hualien County, but did not appear to cause an epidemic and there was no significant increase in the number of severe cases. From the last (2012) EV71 endemic occurring more than four years ago, there is urgent need to understand the cuurent EV71 serostatus of high risk groups and the high transmission population, in order to predict the future epidemic and to set up future enterovirus 71 vaccine policy.We are going to do EV71 seroepidemiology in the northern (Taipei City/New Taipei City), central and southern (Yunlin County/Kaohsiung City), eastern (Hualien County/ Taitung County) Taiwan,and between different regions and between urban and rural regions. After informed consent is obtained, we will enroll the high-risk susceptible groups of EV71 including infants, 1 or 2-year old toddlers, and 3 to 5 year-old kindergarteners, and the high transmission population such as 6-11 year-old primary school students and 12-15 year-old high school students as well as women of childbearing age. They will receive questionnaire investigation and blood sampling, which will be submitted for measuring EV71 neutralization antibody, and thereafter enterovirus 71 Infection rates for all ages will be estimated. This will be of great help to know the prevalence of enterovirus 71 infection in Taiwan at different ages and in different regions. We will also find differences between urban and rural areas as well as gender differences. From the serostatus of the all age groups, we can predict the most susceptible group, which will be put in the first priority to receive EV71 vaccine in the future.腸病毒71型城鄉差距高危險群血清流行病學中和抗體疫苗政策enterovirus 71urban-rural gaphigh-risk groupseroepidemiologyneutralization antibodyvaccine policy