Chiu C.J.WEN-CHUNG LEECHUN-PIN CHIANGHahn L.J.Kuo Y.S.Chen C.J.2020-11-192020-11-1920020022-4006https://www.scopus.com/inward/record.uri?eid=2-s2.0-1542437879&doi=10.1111%2fj.1752-7325.2002.tb03417.x&partnerID=40&md5=aef30a80ccacac6387fbcfa73bab48f5https://scholars.lib.ntu.edu.tw/handle/123456789/521729OBJECTIVES: The aims of the present study were to evaluate the frequent clinical complaints of oral submucous fibrosis (OSF) and to develop a scoring system for early detection of the disease by a self-administered questionnaire. METHODS: A total of 296 subjects were recruited, including 123 OSF patients without oral cancer and 173 betel quid chewers without OSF or oral cancer. A self-administered questionnaire was used to collect the symptom profile from study subjects. Their maximal mouth opening (MMO) between upper and lower incisor edges was measured and recorded by well-trained nurses. A binary logistic regression model examining the likelihood of OSF based on the eight symptoms of interest was used to develop the scoring system. RESULTS: Among 79 OSF subjects with an MMO < 35 mm, the most frequent complaint was trismus (87.3%), followed by burning sensation (76.0%) and xerostomia (72.2%). Among 44 OSF subjects with an MMO > or = 35 mm, burning sensation (68.2%) was the most frequent complaint, followed by trismus (54.5%) and xerostomia (54.5%). Six frequent complaints including trismus, burning sensation, xerostomia, sore throat, numbness, and oral ulceration were utilized to develop a scoring system for the early detection of OSF. The scoring system had an area under the receiver operating characteristic curve of 0.90. CONCLUSION: This study suggests a screening questionnaire of frequent complaints for the early detection of OSF.[SDGs]SDG3adolescent; adult; aged; area under the curve; article; betel nut; early diagnosis; human; hypesthesia; male; middle aged; mouth disease; mouth ulcer; pathophysiology; pharyngitis; questionnaire; roc curve; sensitivity and specificity; statistical model; taste disorder; trismus; xerostomia; Adolescent; Adult; Aged; Area Under Curve; Areca; Early Diagnosis; Humans; Hypesthesia; Logistic Models; Male; Middle Aged; Mouth Diseases; Oral Submucous Fibrosis; Oral Ulcer; Pharyngitis; Questionnaires; ROC Curve; Sensitivity and Specificity; Taste Disorders; Trismus; Xerostomiajournal article10.1111/j.1752-7325.2002.tb03417.x147000862-s2.0-1542437879