CHIH-JUN LAIWEN-CHUN CHANGHsiao C.-F.CHI-HSIANG HUANGYA-JUNG CHENG2021-02-032021-02-0320200929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081649797&doi=10.1016%2fj.jfma.2020.02.013&partnerID=40&md5=322906aa36279388f2d80ec2d138dc83https://scholars.lib.ntu.edu.tw/handle/123456789/546043Increased abdominal pressure is common in obese patients and predisposes them to gastroesophageal regurgitation (GER). To drain GER and prevent aspiration, nasogastric (NG) tubes are frequently inserted in obese patients undergoing general anesthesia. However, whether gastric drainage actually decreases the occurrence of GER remains to be elucidated. In this study, increased abdominal pressure was simulated with laparoscopic pneumoperitoneum and Trendelenburg (LPT) positioning, while the retained NG tube was replaced by a pre-inserted esophageal multichannel intraluminal and pH (MII-pH) monitoring. Fifteen patients undergoing elective gynecologic laparoscopy were enrolled in this study. Thirteen patients (86%) developed GER while in the LPT position. With the high occurrence of GER, pre-inserted NG tubes under general anesthesia are not likely to be protective in obese patients. ? 2020Gastroesophageal regurgitation; Laparoscopic pneumoperitoneum and trendelenburg positioning; Multichannel intraluminal impedance and pH monitoring; Obesity[SDGs]SDG3abdominal pressure; adult; Article; aspiration; body position; clinical article; controlled study; esophageal pH monitoring; gastroesophageal reflux; general anesthesia; human; laparoscopy; obese patient; perioperative period; randomized controlled trial; simulation; complication; esophageal pH monitoring; female; gastroesophageal reflux; gynecologic surgery; impedance; obesity; patient positioning; pH; pressure; Electric Impedance; Esophageal pH Monitoring; Female; Gastroesophageal Reflux; Gynecologic Surgical Procedures; Humans; Hydrogen-Ion Concentration; Laparoscopy; Obesity; Patient Positioning; Perioperative Period; PressurePerioperative gastroesophageal regurgitation in patients with elevated abdominal pressure with nasogastric tubes? A simulation model based on esophageal multichannel intraluminal impedance and pH monitoringjournal article10.1016/j.jfma.2020.02.013321840062-s2.0-85081649797