國立臺灣大學電機工程學系暨研究所鍾孝文2006-07-252018-07-062006-07-252018-07-062004-07-31http://ntur.lib.ntu.edu.tw//handle/246246/8012本計畫之目的在於發展影像分析技 術，用於高空間時間解析度之腦脊髓液動 態流速分析，以估計腦脊髓液產生率。十 九位受試者參與實驗，其中九位分別在下 午與深夜重複兩次實驗。掃瞄影像後以相 關係數分佈圖及區域成長法自動選取大腦 導水管區域進行腦脊髓液產生率自動計 算。所求得健康受試者腦脊髓液產生率約 為332±137 ul/min，與侵入式量測法結果相 符。日間與夜間的腦脊髓液產生率之變化 則不具統計顯著性（p = 0.16）。根據相位 對比磁振造影經過解析度最佳化以及分析 自動化之技術評估，吾人推論以往所報告 之人體腦脊髓液產生率在一日當中的變異 應不明顯。The purpose of this study was to determine the CSF production rate and its possible circadian variations in healthy young adults using cine phase-contrast MR imaging with high temporal and spatial resolutions. 19 healthy adults (15 males, 4 females, 21-39 years of age) were imaged axially perpendicular to the distal third of the aqueduct of Sylvius on a 1.5T system, with 30 cardiac phases at 0.39 mm in-plane resolution. Nine underwent two scans at 1500~1900h and 2100~2400h. Correlation coefficient maps were generated based on pixel-by-pixel analysis of temporal flow patterns, from which the cross-sectional aqueduct area was defined using a region-growing algorithm. CSF production rates were calculated using numerical integration. The automatic segmentation approach yielded average CSF production rate of 332±137 ul/min, which is in good agreement with literature values obtained with invasive ventriculolumbar perfusion measurements. Diurnal change was not statistically significant (292±79 ul/min at ~1700h and 344±179 ul/min at ~2230h, respectively, p = 0.16). Based on MR imaging measurements, a systematic pattern in circadian variations of CSF production rate is not evident in humans.application/pdf49119 bytesapplication/pdfzh-TW國立臺灣大學電機工程學系暨研究所腦脊髓液產生率每日變化磁 振造影相位對比CSF production ratecircadian variationmagnetic resonance imagingphase contrast[SDGs]SDG3reporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/8012/1/922320B002059.pdf