2008-01-012024-05-15https://scholars.lib.ntu.edu.tw/handle/123456789/663115摘要：微流體由於可以應用於微小化生醫晶片，近年來快速發展。研究方向除了連續流體外，電致濕式 （Electrowetting）和熱致趨動式(Thermocapillary)提供兩種達成數位微流體晶片的方法。本計劃將針對熱致趨動式的微流體晶片進行研究。電阻熱趨式微流體晶片(Thermocapillary Actuated Microfluidic Device)主要使用電極進行加熱，利用所產生的溫度梯度進行液珠的趨動、分離、混合液體。技術上最大的挑戰在於如何降低趨動液珠的阻力，以及以小輸入功率產生較高的溫度梯度來增液珠趨動力。由於微流體的面體比(surface to volume ratio)很高，再加上此一微流體晶片表面的液珠通道是經由自組裝單分子鍍層(Self-assembly monolayer)及光微影製程(photolithography)來達成，介面的處理成為一個很重要的課題。 本計劃將利用電極設計、流道幾何形狀設計、以及表面改質來增加液珠的趨動力以及降低液珠移動的阻力。在其他條件相同的狀態下，使用較薄的基板時會產生較高的溫度梯度，此研究計劃將開發軟性塑膠基板的電阻熱趨式微流體晶片製程。 薄膜電晶體陣列已經廣泛使用在主動尋址(Active Addressing)顯示器的背板。在本研究計畫的第二部分，我們將進行薄膜電晶體陣列在塑膠基板上的製程開發，同時使用主動尋址技術於熱趨式微流體晶片，進而達成主動尋址電阻熱趨式微流體晶片。 <br> Abstract: The rapid development of miniature dynamic biochip has attracted much attention. One key component of dynamic biochip is microfluidics. Resistive thermocapillary actuated microfluidic device uses thermal gradient, generated by powering up resistive electrodes, to drive, split, and mix droplets. The main challenges are to reduce the pinning force for driving droplet and to increase the driving force using the same input power. High surface-to-volume ratio is main characteristic for microfluidics. In addition to that, the flow “channels” for this chip are defined by surface modification and photolithography. As a result, interface properties and treatments become the essential issues for the advancing of thermocapillary actuated microfluidic devices. To increase the droplet driving force, we will use numerical simulation to design electrode heaters, and geometrical flow channels; on the other hand, the reduction of droplet pinning force will be accomplished by surface treatment. Higher thermal gradient can be achieved by using thinner substrates; we will, therefore, develop microfluidic chip fabrication process on flexible plastic substrate. Thin film transistor array has been applied extensively to display backplane. The second part of this research plan is to apply this technology as the backplane to implement active addressing thermocapillary actuated microfluidic device.熱趨式微流體晶片數位微流體晶片軟性光機電系統薄膜電晶體陣列主動尋址顯示器Thermocapillary actuated microfluidic deviceDigital MicrofluidicsFlexible optoelectromechanical systemThin film transistor arrayActive addressingDisplay