Proton Pump Inhibitor-unresponsive Laryngeal Symptoms Are Associated With Psychological Comorbidities and Sleep Disturbance: A Manometry and Impedance-pH Monitoring Study

Wen-Hsuan TsengLee, Hui-ChuanHui-ChuanLeeWEI-CHUNG HSUTZU-YU HSIAOJIA-FENG WUTSUNG-LIN YANGHSIU-PO WANGMING-SHIANG WUPING-HUEI TSENG2023-09-252023-09-252023-07-302093-0879https://pubmed.ncbi.nlm.nih.gov/37417258/https://scholars.lib.ntu.edu.tw/handle/123456789/635769Laryngeal symptoms are largely treated with empiric proton pump inhibitor (PPI) therapy if no apparent pathology shown on ear, nose, and throat evaluation and reflux-related etiologies are suspected. However, treatment response remains unsatisfactory. This study aimed to investigate the clinical and physiological characteristics of patients with PPI-refractory laryngeal symptoms.enGastroesophageal reflux; Larynx disease; Manometry; Psychological factors; Sleep disorder[SDGs]SDG3Proton Pump Inhibitor-unresponsive Laryngeal Symptoms Are Associated With Psychological Comorbidities and Sleep Disturbance: A Manometry and Impedance-pH Monitoring Studyjournal article10.5056/jnm22099374172582-s2.0-85166024435https://api.elsevier.com/content/abstract/scopus_id/85166024435