2023-01-012024-05-14https://scholars.lib.ntu.edu.tw/handle/123456789/658914精準營養 (precision nutrition) 是針對個體 (individuals) 或者人口亞群 (population subgroups) 的健康或營養需求，設計出具有目的性及標的性的營養方案。根據國際營養遺傳學/營養學學會 (International Society of Nutrigenetics/Nutrigenomics, ISNN) 定義，精準營養是將年齡、性別或其他變因將人口分為人口亞群，依照不同層級分為分層營養 (stratified nutrition)、個人化營養 (individualized nutrition) 和基因定向營養 (genotype-directed nutrition)，並基於遺傳和生理表現提供最適的營養指南。老化 (aging) 和衰弱症 (frailty) 是全身器官連續性的生理功能退化，進而使高齡者更容易受到疾病的侵襲及感染。近年來，台灣目前因人口高齡化，導致高齡者之特殊營養品需求及市場日益擴張，市面上健康及保健食品種類繁多，但卻缺乏針對特定族群完整的預防及營養對策。有鑑於大數據 (big data) 和非關聯型資料庫 (NoSQL) 技術成熟，SNP (Single Nucleotide Polymorphism) 及腸道菌相 (gut microbiota) 資料庫的建立皆能提供更多的精準營養對策的判定依據，科學脈診儀的應用和數據資料蒐集建立，亦可作為精準營養對策的生物指標 (biomarker)。此外，目前保健及健康食品多著重於各種已知生物活性分子 (nutraceuticals) 的應用與開發，因此建立一套針對改善老化相關疾病的活性成分資料庫亦可使後續應用層面更加完善。透過整合上述多重資料庫以建立精準個人營養平台，除了能夠提供個人化之最適營養指南外，亦有助於後續食品及醫療業者研究與開發。本計畫亦將結合基因編輯技術藉此提供具改善老化相關疾病的水稻原料，以提供高質量食品原料，並以新穎之非熱加工技術，如低溫大氣電漿提升營養成分和機能性成分的含量或吸收率。綜上所述，本計畫將串聯資料庫及平台的建立，並依據其成果加以應用，研發出最符合高齡營養需求之功能性產品。此計畫不僅將學術知識提升至實務應用層面，亦能幫助高齡者積極面對老化的過程，並有效減緩老化及對抗相關病症，對於國人健康與國家經濟皆有更直接與長遠的效益。 Precision Nutrition (PN) is a strategy for designing comprehensive, objective, and dynamic nutritional guidelines based on the health or nutrition demand of individual variables or population subgroups. According to the definition of International Society of Nutrigenetics/Nutrigenomics (ISNN), PN classifies people as population subgroup by age, sex, or other factors, further divides into stratified, individualized, and genotype-directed nutrition, and provides the optimal nutrition guideline based on the genetic and health status. Aging and frailty referred to the continuous decline and deterioration of functions in body’s organs. These functional properties loss increases the vulnerability to disease. Recently, the nutritional supplements demand and market for the elder are dramatically raised due to population aging. However, although there are various of health supplements on the market, it lacks comprehensive guidelines for nutritional supplement and preventive strategy. Due to the development of big data and NoSQL database, establishment of Single Nucleotide Polymorphism (SNP) and gut microbiota database could be used as the basis to provide the more precise nutrition strategy, the construction of the pulse wave database and the application of pulse diagnosis instrument also could be applied as the biomarker for precision nutrition approach. Moreover, because health care and health foods currently focus on the application and development of various nutraceuticals, establishing a comprehensive bioactivity compounds database to improve aging and aging-related diseases also could aid the downstream application. Therefore, in this project, we mainly aim to construct a platform (named as NUtrition Requirement prEdiction based on microbial COmpositioN, NURECON) by integrating the above databases. This platform can be used as a tool to provide the guidelines for nutritional supplements and also can assist in the development of food and medicine. Moreover, according to nutritional demand, it could be expected to promote functional nutrient production in rice and produce functional foods with easily consumed by using genomic editing technology and plasma technology, respectively. It is the prospect of implementing this project that could improve the physiological and health quality of the elderly, meanwhile, reducing the expenditure of medical resources by preventive strategy and provide new insight into the prevention and therapy of diseases.精準營養;老化;衰弱症;腸道菌相;NURECON;precision nutrition;aging;frailty;gut microbiota;ＮURECON