BAI-CHIN LEEHsu H.-C.WEN-YIH TSENGMAO-YUAN SUSSU-YUAN CHENYEN-WEN WUKUO-LIONG CHIENMING-FONG CHEN2020-03-032020-03-0320091355-6037https://www.scopus.com/inward/record.uri?eid=2-s2.0-67649236985&doi=10.1136%2fhrt.2008.153510&partnerID=40&md5=023f39b21126a4b14eeebf3b8477c25ahttps://scholars.lib.ntu.edu.tw/handle/123456789/468777Objective: To determine whether cardiac rehabilitation influences plasma levels of angiogenic cytokines and their correlation with myocardial blood flow (MBF). Design: Randomised controlled study. Setting: Tertiary cardiac centre. Patients: 39 postinfarction patients randomised to either a 3-month training group (n = 20) or a non-training group (n = 19), and 19 normal controls. Interventions: Cardiac rehabilitation. Main outcome measures: MBF by cardiac magnetic resonance imaging, and plasma levels of stem cell factor (SCF), stromal-derived factor-1 (SDF-1), and vascular endothelial growth factor (VEGF) measured at enrolment and at 3 months after randomisation. Results: At baseline, when compared with the healthy subjects, postinfarction patients had a lower MBF in the infarcted myocardium during dipyridamole-induced stress (1.65 (0.58) vs 2.77 (0.78) ml/min/g, p<0.001) but higher plasma levels of VEGF (3.65 (0.75) vs 2.77 (0.59) pg/ml, p<0.001 expressed as the natural logarithm) and SDF-1 (2113 (345) vs 1869 (309) pg/ml, p = 0.009). Only SDF-1 was inversely associated with stress MBF in both remote (r = -0.39, p = 0.03) and infarcted myocardium (r = -0.62, p<0.001). After 3 months, the training group's stress MBF had increased by 33% in the remote (p<0.001) and 28% in infarcted myocardium (p = 0.02), while VEGF decreased by 9% (p = 0.01), and SDF-1 decreased by 11% (p = 0.02). The change in SDF-1 was inversely correlated with the change in stress MBF in both remote (r = -0.40, p = 0.01) and infarcted myocardium (r = -0.50, p = 0.001). In the non-training group, MBF and cytokines were unchanged. Conclusion: Cardiac rehabilitation improves stress MBF in postinfarction patients, with an inverse decrease in circulating angiogenic cytokines.[SDGs]SDG3dipyridamole; stem cell factor; stromal cell derived factor 1; vasculotropin; adult; aged; angiogenesis; article; clinical article; clinical trial; controlled clinical trial; controlled study; heart infarction; heart muscle blood flow; heart rehabilitation; heart stress; human; male; nuclear magnetic resonance imaging; priority journal; protein blood level; randomized controlled trial; Adult; Aged; Angiogenesis Inducing Agents; Biological Markers; Chemokine CXCL12; Coronary Circulation; Cytokines; Exercise Test; Exercise Therapy; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Myocardial Infarction; Neovascularization, Physiologic; Stem Cell Factor; Vascular Endothelial Growth Factor Ajournal article10.1136/hrt.2008.153510193046682-s2.0-67649236985