2023-01-012024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/653655骨頭本身的壓電特性以及壓電刺激在骨癒合中所扮演的角色，已逐漸在近期的骨癒合研究領域受到重視。水膠也因其接近細胞外間質的特性，廣泛地被應用在再生醫學的組織培養以及疾病模型的研究。本計畫結合壓電刺激與水膠細胞培養，探討椎間盤退化過程中的病變環境模型，以及外部刺激如超音波如何在此類環境中激發壓電刺激而影響細胞的發展。本研究能夠針對軟骨組織再生，以及壓電刺激對退化環境中的髓核細胞發展提供第一手的觀察數據，有助於建立針對軟骨組織傷害與椎間盤退化的治療方法。 Accumulating evidence has demonstrated the relevance of piezoelectricity in bones and how piezoelectric stimulation might help accelerate bone healing. On the other hand, hydrogels are widely recognized for their ability to mimic extracellular matrix, especially for creating tissues in vitro for regenerative medicine and disease modeling. In this study, we proposed to integrate piezoelectric stimulation with hydrogel cell cultures. The objective is to model the degenerative environment in the intervertebral disc and explore how external stimuli, such as ultrasound, can influence cells in such environment with the induced piezoelectric effect. The insights obtained in this study could provide further understanding on how to establish therapeutic treatments for degenerative intervertebral discs or damaged cartilages.壓電刺激; 軟骨;piezoelectric stimulation; cartilage