YU-JEN FANGLee, Kun-HuaKun-HuaLeeKarmakar, RiyaRiyaKarmakarMukundan, ArvindArvindMukundanNagisetti, YaswanthYaswanthNagisettiHuang, Chien-WeiChien-WeiHuangWang, Hsiang-ChenHsiang-ChenWang2026-01-282026-01-282025-10-28https://www.scopus.com/pages/publications/105021431423?inwardhttps://scholars.lib.ntu.edu.tw/handle/123456789/735643: Esophageal cancer (EC) is a major global health issue due to its high mortality rate, as patients are often diagnosed at advanced stages. This research examines whether the Spectrum-Aided Vision Enhancer (SAVE), a hyperspectral imaging (HSI) technique, enhances endoscopic image categorization for superior diagnostic outcomes compared to traditional White Light Imaging (WLI) and Narrow Band Imaging (NBI). : A dataset including 2400 photos categorized into eight disease types from National Taiwan University Hospital Yun-Lin Branch was utilized. Multiple machine learning and deep learning models were developed, including logistic regression, VGG16, YOLOv8, and MobileNetV2. SAVE was utilized to transform WLI photos into hyperspectral representations, and band selection was executed to enhance feature extraction and improve classification outcomes. The training and evaluation of the model incorporated precision, recall, F1-score, and accuracy metrics across WLI, NBI, and SAVE modalities. : The research findings indicated that SAVE surpassed both NBI and WLI by achieving superior precision, recall, and F1-scores. Logistic regression and VGG16 performed with a comparable reliability to SAVE and NBI, whereas MobileNetV2 and YOLOv8 demonstrated inconsistent yet enhanced results. Overall, SAVE exhibited exceptional categorization precision and recall, showcasing impeccable performance across many models. : This research indicates that AI hyperspectral imaging facilitates early diagnosis of esophageal diseases, hence enhancing clinical decision-making and improving patient outcomes. The amalgamation of SAVE with machine learning and deep learning models enhances diagnostic capabilities, with SAVE and NBI surpassing WLI by offering superior tissue differentiation and diagnostic accuracy.enMobileNetV2VGG16YOLOv8esophageal cancerhyperspectral imaginglogistic regressionprincipal component analysisspectrum-aided vision enhancerjournal article10.3390/diagnostics1521273241226023