Serum free 1,25-dihydroxy-vitamin D is more closely associated with fibroblast growth factor 23 than other vitamin D forms in chronic dialysis patients

CHIA-TER CHAOSZU-YING LEECHUNG-JEN YENCHIH-KANG CHIANGJENQ-WEN HUANGKUAN-YU HUNG2020-10-142020-10-1420150009-8981https://www.scopus.com/inward/record.uri?eid=2-s2.0-84908592493&doi=10.1016%2fj.cca.2014.10.022&partnerID=40&md5=acd752358270411c0a18d5d1b310e6b1https://scholars.lib.ntu.edu.tw/handle/123456789/516895Background: Mineral bone disorder (MBD) is prevalent among chronic dialysis patients. However, relationship between different forms of vitamin D and fibroblast growth factor 23 (FGF-23) remains unclear in this population. Methods: A multicenter hemodialysis cohort was assembled. We evaluated 25-OH-D and 1,25-(OH)2-D, vitamin D-binding protein, and FGF-23, in this cohort. Multiple regression analyses were performed to investigate the relationship and stewardship between different vitamin D forms and FGF-23 concentrations. Results: Chronic dialysis patients presented significantly higher FGF-23 concentrations. 25-OH-D concentrations of <20ng/ml (deficiency), 20-30ng/ml (insufficiency), and ?30ng/ml (sufficiency) were associated with progressively lower FGF-23 concentrations (p<0.01). Serum FGF-23 concentrations were significantly correlated with total (p=0.02), free (p<0.01) and bioavailable (p<0.01) 25-OH-D and total (p=0.04), free (p=0.02), and bioavailable (p=0.03) 1,25-(OH)2-D concentrations. With all 25-OH-D and 1,25-(OH)2-D forms in the regression model, we found that free 1,25-(OH)2-D outweighed all other vitamin D forms regarding its association with FGF-23 (p=0.03). Conclusion: The relationship between FGF-23 and vitamin D is stronger using free forms of 25-OH-D and 1,25-(OH)2-D. Subsequent studies aiming at MBD should consider including free 25-OH-D and 1,25-(OH)2-D in the analysis. ? 2014 Elsevier B.V.[SDGs]SDG3fibroblast growth factor 23; Fibroblast Growth Factors; Vitamin D; aged; analogs and derivatives; blood; Female; Humans; Male; Regression Analysis; Renal Dialysis; Aged; Female; Fibroblast Growth Factors; Humans; Male; Regression Analysis; Renal Dialysis; Vitamin DSerum free 1,25-dihydroxy-vitamin D is more closely associated with fibroblast growth factor 23 than other vitamin D forms in chronic dialysis patientsjournal article10.1016/j.cca.2014.10.022254519472-s2.0-84908592493