Mild Chronic Colitis Triggers Parkinsonism in LRRK2 Mutant Mice Through Activating TNF-α Pathway

CHIN-HSIEN LINLin, Han-YiHan-YiLinHo, En-PongEn-PongHoKe, Yi-CiYi-CiKeMEI-FANG CHENGShiue, Chyng-YannChyng-YannShiueWu, Chi-HanChi-HanWuLiao, Peng-HsiangPeng-HsiangLiaoHsu, Angela Yu-HueyAngela Yu-HueyHsuChu, Li-AnLi-AnChuLiu, Ya-DingYa-DingLiuLin, Ya-HuiYa-HuiLinTai, Yi-ChengYi-ChengTaiCHIA-TUNG SHUNHAN-MO CHIUMING-SHIANG WU2022-05-172022-05-172022-040885-3185https://scholars.lib.ntu.edu.tw/handle/123456789/611146Leucine-rich repeat kinase 2 (LRRK2) is a common risk gene for Parkinson's disease (PD) and inflammatory bowel disorders. However, the penetrance of the most prevalent LRRK2 mutation, G2019S, is <50%. Factors other than genetic mutations are needed in PD process.enParkinson's diseasegut inflammationinflammatory bowel diseasegut-brain axisleucine-rich repeat kinase 2tumor necrosis factor-alphaMild Chronic Colitis Triggers Parkinsonism in LRRK2 Mutant Mice Through Activating TNF-α Pathwayjournal article10.1002/mds.28890349187812-s2.0-85121399663WOS:000731075600001https://scholars.lib.ntu.edu.tw/handle/123456789/592405