倪衍玄2006-07-262018-07-112006-07-262018-07-112000http://ntur.lib.ntu.edu.tw//handle/246246/22851Helicobacter pylori (H. pylori) infection has been associated with gastritis, peptic ulcer, and gastric malignancy. Invasive and noninvasive tests have been developed for the diagnosis of H. pylori infection. Since H. pylori infection is mostly acquired in childhood and adolescence, accurate diagnosis of the infection in the pediatric population is important. The noninvasive diagnostic methods are particularly feasible in children. We conducted a study to compare the invasive tests: culture, biopsy urease test (BUT), histology, and polymerase chain reaction (PCR) on gastric biopsy specimens, with noninvasive tests: serology, 13C-urea breath test (13C-UBT), and a new diagnostic modality: stool antigen test to diagnose H. pylori infection in children. A total of 53 symptomatic children were enrolled into this study and all had completed the seven diagnostic tests for H. pylori. Our results showed all the diagnostic tests except serology were excellent methods of diagnosing H. pylori infection in children. The diagnostic accuracy of the seven tests were as follows: stool antigen test 96.2%; BUT 96.2%; histology 98.1%; PCR 94.3%; culture 98.1%; 13CUBT 100%; and serology 84.9%. Stool antigen test, being highly sensitive and specific as shown in our data, will be potentially very helpful in diagnosing H. pylori infection in children.application/pdf59267 bytesapplication/pdfzh-TW國立臺灣大學醫學院小兒科Helicobacter pyloriurease13C-urea breath teststool antigen testserologyreporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/22851/1/892314B002142.pdf