Lee Y.-C.Kuo H.-C.Chang J.-S.LUAN-YIN CHANGLI-MIN HUANGChen M.-R.Liang C.-D.Chi H.Huang F.-Y.Lee M.-L.Huang Y.-C.Hwang B.Chiu N.-C.Hwang K.-P.Lee P.-C.Chang L.-C.Liu Y.-M.Chen Y.-J.Chen C.-H.Chen Y.-T.Tsai F.-J.Wu J.-Y.2020-12-152020-12-1520121061-4036https://www.scopus.com/inward/record.uri?eid=2-s2.0-84862814732&doi=10.1038%2fng.2227&partnerID=40&md5=6c4166fcde7e57e58839d98fe3d551c0https://scholars.lib.ntu.edu.tw/handle/123456789/525569To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10 -8). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis. ? 2012 Nature America, Inc. All rights reserved.[SDGs]SDG3B lymphoid tyrosine kinase; CD40 antigen; protein tyrosine kinase; unclassified drug; article; controlled study; gene locus; gene replication; genetic association; genetic risk; genetic susceptibility; genotype; human; intron; mucocutaneous lymph node syndrome; priority journal; single nucleotide polymorphism; Case-Control Studies; Genetic Loci; Genetic Markers; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Mucocutaneous Lymph Node Syndrome; Polymorphism, Single Nucleotide; Taiwanjournal article10.1038/ng.2227224469612-s2.0-84862814732