Liu W.-L.FU-TIEN CHIANGKao J.T.-W.Chiou S.-H.Lin H.-L.2021-03-112021-03-1120200167-4889https://scholars.lib.ntu.edu.tw/handle/123456789/551607GSK3 are involved in different physical and pathological conditions and inflammatory regulated by macrophages contribute to significant mechanism. Infection stimuli may modulate GSK3 activity and influence host cell adaption, immune cells infiltration or cytokine expressions. To further address the role of GSK3 modulation in macrophages, the signal transduction of three major organs challenged by endotoxin, virus and genetic inherited factors are briefly introduced (lung injury, myocarditis and autosomal dominant polycystic kidney disease). As a result of pro-inflammatory and anti-inflammatory functions of GSK3 in different microenvironments and stages of macrophages (M1/M2), the rational resolution should be considered by adequately GSK3. ? 2020 Elsevier B.V.HMGB1/IL-17A/autophagy; M1/M2 macrophages; Mitotic catastrophe; PI3K/Akt/GSK3β/MCP-1 axis; Podocyte; Pulmonary edema[SDGs]SDG3cytokine; endotoxin; glycogen synthase kinase 3; glycogen synthase kinase 3beta; macrophage migration inhibition factor; monocyte chemotactic protein 1; glycogen synthase kinase 3beta; GSK3B protein, human; acute lung injury; adult respiratory distress syndrome; aneurysm; cell infiltration; cell migration; cholinergic system; congestive cardiomyopathy; disease association; heart protection; human; immunocompetent cell; immunomodulation; infection; inflammation; kidney polycystic disease; macrophage; myocarditis; nonhuman; priority journal; protein expression; renal protection; Review; signal transduction; acute lung injury; aneurysm; genetics; kidney polycystic disease; lung injury; metabolism; myocarditis; pathology; Acute Lung Injury; Aneurysm; Glycogen Synthase Kinase 3 beta; Humans; Lung Injury; Macrophages; Myocarditis; Polycystic Kidney Diseasesreview10.1016/j.bbamcr.2020.118798326931092-s2.0-85089002201