Hsieh Y.-C.PO-REN HSUEHCHUN-YI LUPING-ING LEELee C.-Y.LI-MIN HUANG2020-03-272020-03-2720041058-4838https://scholars.lib.ntu.edu.tw/handle/123456789/480419Recently, there have been increasing numbers of pneumococcal pneumonia cases, with their associated complications. We conducted a retrospective review to increase the understanding of childhood pneumococcal pneumonia. Seventy-one patients with pneumococcal pneumonia were identified. Forty (56.3%) of them developed complicated pneumonia. Multivariate analysis showed that presence of immature polymorphonuclear leukocytes in peripheral blood (odds ratio [OR], 3.67; 95% confidence interval [CI], 1.08-12.63), high C-reactive protein levels (>12 mg/dL) (OR, 5.24; 95% CI, 1.10-24.93), and no underlying disease at presentation (OR, 5.48; 95% CI, 1.06-28.25) were independent predictors of the occurrence of necrosis or/and abscess. Fourteen isolates (35%), which were genotypically identical and had the same pulsed-field gel electrophoresis pattern (serogroup 14, with MICs of penicillin of 0.1-0.5 μg/mL), were significantly associated with complicated pneumonia (P = .047). Whether the virulence of antibiotic-resistant pneumococci is evolving deserves further investigation.[SDGs]SDG3C reactive protein; ceftriaxone; penicillin G; antiinfective agent; abscess; adolescent; antibiotic resistance; antibiotic sensitivity; bacterial virulence; child; clinical feature; empyema; female; genotype; human; infant; infection complication; lobar pneumonia; major clinical study; male; minimum inhibitory concentration; multivariate analysis; necrosis; neutrophil; nonhuman; pediatrics; priority journal; pulsed field gel electrophoresis; review; Streptococcus pneumoniae; Taiwan; article; drug effect; empyema; epidemiology; genetics; lobar pneumonia; microbiological examination; preschool child; retrospective study; Taiwan; Anti-Bacterial Agents; Child, Preschool; Drug Resistance, Bacterial; Empyema; Epidemiology, Molecular; Female; Humans; Infant; Male; Microbial Sensitivity Tests; Pneumonia, Pneumococcal; Retrospective Studies; Streptococcus pneumoniae; Taiwanreview10.1086/381974149996272-s2.0-1642285878