Shih Y.-H.Peng C.-L.Luo T.-Y.MING-JIUM SHIEH2020-02-272020-02-272013https://www.scopus.com/inward/record.uri?eid=2-s2.0-84881100055&partnerID=40&md5=957e5e13d436a534bf060ab0302519e1https://scholars.lib.ntu.edu.tw/handle/123456789/465758In this study, multi-functional micelles loaded with doxorubicin (Dox) and labeled with the radionuclide rhenium-188 (188Re) were developed to provide the combination therapy for liver cancer. BNL/Luc heptoma mice were randomly allocated to four groups. Including PBS control (n=4), 88Re- perrhenate (n=4), Dox micelles (n=5) and 188Re Dox-micelles (n=5). The biodsitribution and therapeutic efficacy were mesured. Bio-luminescence imaging of BNL/Luc heptoma showed the smallest tumor size in 188Re-Dox micelles group (p<0.05). Moreover, 188Re-Dox micelles group had more than thirty days survival, which was significantly different with control (p<0.005). Immunohistochemical staining of proliferating cell nuclear antigen (PCNA) shows that 188Re-Dox micelles inhibited the proliferation of BNL/Luc cell comparing with control (p<0.001). We suggested the 188Re Dox-micelles could apply for the combined therapies of hepatoma.Doxorubicin; Micelles; PCNA; Rhenium-188[SDGs]SDG3Combination therapy; Doxorubicin; Hepatocellular carcinoma; Immunohistochemical staining; PCNA; Proliferating cell nuclear antigens; Rhenium-188; Therapeutic efficacy; Cell proliferation; Chemotherapy; Exhibitions; Films; Nanocomposite films; Nanotechnology; Rhenium; Micellesconference paper2-s2.0-84881100055