放射線科YEN, RUOH-FANGRUOH-FANGYENTING, LAI-LEILAI-LEITINGCHENG, MEI-FANGMEI-FANGCHENGWU, YEN-WENYEN-WENWUTZEN, KAI-YUANKAI-YUANTZENHONG, RUEY-LONGRUEY-LONGHONG2010-07-082018-07-122010-07-082018-07-122009http://ntur.lib.ntu.edu.tw//handle/246246/188642Background. This study was designed to compare (TI)-T-201 single photon emission computed tomography (SPECT)/CT with 18-fluoro-2-deoxyglucose (F- 18-FDG) PET/CT in diagnosing recurrent skull base nasopharyngeal carcinoma (NPC). Methods . Twenty-seven patients were recruited. Both (TI)-T-201 SPECT/CT and F-18-FDG PET/CT for each patient were performed at least 4 months later after initial therapy. Results. The sensitivity and specificity for (TI)-T-201 SPECT/CT were 66 .7% and 100%, and those for F- 18-FDG PET/CT were 86.7% and 75.0%. Lesion/background ratios were obtained for the 10 lesions that were both SPECT and PET true positive. For the 8 patients with recurrences in nasopharyngeal regions, PET lesion/background ratios were all higher than SPECT lesion/ background ratios. For the 2 patients with intracranial metastases, SPECT lesion/background ratios were higher than PET lesion/background ratios. Conclusion. (TI)-T-201 SPECT/ CT is as effective as F-18-FDG PET/CT in detecting recurrent NPC. For intracranal recurrence, (TI)-T-201 SPECT, because of its high intracranial lesion/background ratio, is probably better than F-18-FDG PET.en-US(TI)-T-201 SPECT/CTF-18-FDG PET/CTnasopharyngeal carcinomarecurrenceskull base