HSIN-YUN SUNCHI-TAI FANGJANN-TAY WANGPING-HUNG KUOYEE-CHUN CHENSHAN-CHWEN CHANG2020-12-232020-12-2320060929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-31144455421&doi=10.1016%2fS0929-6646%2809%2960114-5&partnerID=40&md5=6c77cfa30aed17002ae809deda5ce1dehttps://scholars.lib.ntu.edu.tw/handle/123456789/530862Treatment of cerebral malaria with intravenous quinine is frequently associated with life-threatening cardiotoxicity. We report a case of imported cerebral malaria successfully treated with artesunate-mefloquine combination therapy. The 27-year-old woman presented with fever, sudden onset of binocular blindness and altered consciousness 10 days after a short stay in Indonesia. Hyperparasitemia with Plasmodium falciparum and P. vivax in more than 5% of red blood cells was demonstrated on peripheral blood smear. She was admitted to the intensive care unit due to shock, jaundice and acute renal failure. Because of a shortage of intravenous quinine, intravenous artesunate was given as an alternative. Her condition stabilized on the 3rd day of therapy, with resolution of fever and disappearance of parasitemia. Consolidation therapy with oral mefloquine and primaquine was then given to prevent recrudescence and relapse. The only adverse event associated with artesunate was transient reticulocytopenia, which resolved after discontinuation of therapy. Her vision completely recovered, along with renal and liver function. ?2006 Elsevier & Formosan Medical Association.[SDGs]SDG3artesunate; aspartate aminotransferase; bilirubin; creatinine; hemoglobin; lactate dehydrogenase; mefloquine; nitrogen; primaquine; quinine; urea; adult; anamnesis; anemia; article; bilirubin blood level; brain malaria; brain scintiscanning; case report; clinical feature; computer assisted tomography; creatinine blood level; cytopenia; drug substitution; encephalitis; eradication therapy; female; hematocrit; hemoglobin determination; human; laboratory test; leukocyte count; nuclear magnetic resonance imaging; parasitemia; reticulosis; thrombocyte count; travel; treatment outcome; treatment withdrawal; urea nitrogen blood level; urinalysisjournal article10.1016/S0929-6646(09)60114-5164400762-s2.0-31144455421