KAI-HSIN LIN2018-09-102018-09-101998http://www.scopus.com/inward/record.url?eid=2-s2.0-0031924652&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/344207Purpose: To investigate the response of erythropoietin (EPO) to anemia in patients polytransfused for β-thalassemia major. Patients and Methods: We measured the serum EPO levels and the concurrent hemoglobin (Hb) concentrations in 40 patients polytransfused for β-thalassemia major, in 18 patients with iron deficiency anemia (IDA), and 32 healthy subjects. Serum EPO levels were assayed by an enzyme immunoassay. Results: In both groups with β-thalassemia major and IDA, serum EPO levels were significantly elevated (114 ± 71 and 239 ± 217 mU/mL, respectively). There was a significant inverse correlation between log EPO values and Hb concentrations in patients with β-thalassemia major (r = 0.61; p <0.01) and IDA (r = 0.81; p <0.01). In a semilogarithmic plot, the slope of the regression line obtained in patients with β-thalassemia major was significantly lower than that of IDA (p <0.01), suggesting a blunted EPO response to anemia in patients polytransfused for β-thalassemia major. The elevation of serum EPO in patients with β-thalassemia major was poorly related to clinical variables except serum ferritin. Conclusions: We conclude that a significant inverse relationship between serum EPO levels and Hb concentration exists in patients with β-thalassemia major. However, this EPO response in patients with anemia caused by β-thalassemia major may be blunted when compared to patients with IDA.β-thalassemia major; Erythropoietin[SDGs]SDG3erythropoietin; hemoglobin; adolescent; adult; article; blood transfusion; child; clinical article; controlled study; enzyme immunoassay; female; human; iron deficiency anemia; male; priority journal; thalassemia major; Adolescent; Adult; Anemia, Iron-Deficiency; beta-Thalassemia; Blood Transfusion; Child; Child, Preschool; Erythropoietin; Female; Ferritins; Hemoglobins; Humans; Immunoenzyme Techniques; Infant; Male; Mutationjournal article10.1097/00043426-199803000-00010