CHE-MING TENG2018-09-102018-09-102010http://www.scopus.com/inward/record.url?eid=2-s2.0-77349116794&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/355013As part of our continuing search for potential anticancer drug candidates among YC-1 analogs, 1, 3-disubstituted selenolo[3,2-c]pyrazole derivatives were synthesized and evaluated for their cytotoxicity against NCI-H226 non-small cell lung cancer and A-498 renal cancer cell lines. Significant cytotoxicity was observed in 3-(5-hydroxymethyl-2-furyl) derivatives (2, 33, 36 and 37). Among them, compound 2 was found to have the most potent activity. The mode of action of compound 2 seems to differ from those of the 175 anticancer agents listed in NCI's standard database and resembles that of YC-1. Thus, we recommend that compound 2 should be developed further as new drug candidate for treatment of non-small cell lung cancer and renal cancer. ? 2009 Elsevier Masson SAS. All rights reserved.Cytotoxicity; Furopyrazole; Selenolopyrazole; Structure-activity relationships (SAR); Thienopyrazole; YC-1 analogs[SDGs]SDG31 benzyl 3 (4 hydroxycarbonylphenyl)selenolo[3,2 c]pyrazole; 1 benzyl 3 (4 hydroxymethylphenyl)selenolo[3,2 c]pyrazole; 1 benzyl 3 (4 methoxycarbonylphenyl)selenolo[3,2 c]pyrazole; 1 benzyl 3 (5 hydroxycarbonyl 2 furyl)selenolo[3,2 c]pyrazole; 1 benzyl 3 (5 hydroxymethyl 2 furyl) 5 methylselenolo[3,2 c]pyrazole; 1 benzyl 3 (5 hydroxymethyl 2 furyl)selenolo[3,2 c]pyrazole; 1 benzyl 3 (5 methoxycarbonyl 2 furyl) 5 methylselenolo[3,2 c]pyrazole; 1 benzyl 3 (5 methoxycarbonyl 2 furyl)selenolo[3,2 c]pyrazole; 1 phenyl 3 (4 hydroxymethylphenyl)selenolo[3,2 c]pyrazole; 1 phenyl 3 (4 methoxycarbonylphenyl)selenolo[3,2 c]pyrazole; 1 phenyl 3 (5 hydroxycarbonyl 2 furyl) 5 methylselenolo[3,2 c]pyrazole; 1 phenyl 3 (5 hydroxycarbonyl 2 furyl)selenolo[3,2 c]pyrazole; 1 phenyl 3 (5 hydroxymethyl 2 furyl) 5 methylselenolo[3,2 c]pyrazole; 1 phenyl 3 (5 hydroxymethyl 2 furyl)selenolo[3,2 c]pyrazole; 1 phenyl 3 (5 methoxycarbonyl 2 furyl) 5 methylselenolo[3,2 c]pyrazole; 1 phenyl 3 (5 methoxycarbonyl 2 furyl)selenolo[3,2 c]pyrazole; antineoplastic agent; pyrazole derivative; unclassified drug; article; cancer cell culture; controlled study; cytotoxicity; drug potency; drug screening; drug structure; drug synthesis; human; human cell; IC 50; kidney cancer; lung non small cell cancer; Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Pyrazoles; Spectrophotometry, Infraredjournal article10.1016/j.ejmech.2009.12.039