Liao, Yi-AnYi-AnLiaoPeng, Wen-ShengWen-ShengPengLiu, Ling-JunLing-JunLiuYe, Ting-YouTing-YouYeFu, Jun-HaoJun-HaoFuYI-TSU CHANTsai, Fu-YuFu-YuTsai2023-04-262023-04-262022-11-040022-3263https://scholars.lib.ntu.edu.tw/handle/123456789/630641An iron-based catalytic system was developed for the cross-coupling of 1-bromoalkynes with terminal alkynes to selectively generate unsymmetrical 1,3-butadiynes in water under air. It was found that a combination of 1-bromoalkynes derived from less acidic terminal alkynes with more acidic counterparts would greatly enhance yields and selectivity for unsymmetrical 1,3-butadiynes. The reaction was also applicable for the synthesis of unsymmetrical 1,3,5-hexatriynes through coupling of 1-bromoalkynes and trimethylsilyl-protected 1,3-butadiynes in a one-pot manner.enONE-POT SYNTHESIS; TERMINAL ALKYNES; UNSYMMETRICAL 1,3-DIYNES; EFFICIENT SYNTHESIS; ROOM-TEMPERATURE; IN-SITU; LIGAND; COPPER; 1-BROMOALKYNES; SYSTEM[SDGs]SDG6journal article10.1021/acs.joc.2c01354361647652-s2.0-85139203382WOS:000862799700001https://api.elsevier.com/content/abstract/scopus_id/85139203382