Lu, ChingChingLuCHAO LUN LAIYang, Chih-ManChih-ManYangLiao, Karen Chia-WenKaren Chia-WenLiaoKao, Chie-ShungChie-ShungKaoChang, Tien-ChuTien-ChuChangPerng, Ming-DerMing-DerPerng2023-09-082023-09-082022-11-291010660Xhttps://www.scopus.com/record/display.uri?eid=2-s2.0-85144550572&doi=10.3390%2fmedicina58121748&origin=inward&txGid=aef8be5f5c5788efcb67a6c21732d4e4https://scholars.lib.ntu.edu.tw/handle/123456789/635306Background and Objectives: The aim of this study was to investigate the relationships between obesity-related factors including body mass index (BMI), diabetes or prediabetes, hyperlipidemia, fasting plasma glucose, fasting plasma insulin, homeostasis model assessment-estimated insulin resistance (HOMA-IR), highly sensitive C-reactive protein (hs-CRP) and Graves' orbitopathy (GO). Materials and Methods: Eighty-four patients with Graves' disease (GD) (42 without GO and 42 with GO) were enrolled in this cross-sectional cohort study. Gender, age, GD treatment history, height, body weight, waist circumference, smoking status, co-morbidities, levels of free thyroxin, thyroid-stimulating hormone, thyroid-stimulating hormone receptor (TSHR) antibodies, fasting plasma glucose and insulin, and hs-CRP were recorded. The eye condition was evaluated using the consensus statement of the European Group of Graves' Orbitopathy (EUGOGO) and the NOSPECS classification. Results: In this study, multivariate regression analysis showed that BMI, fasting plasma insulin, and HOMA-IR were associated with the presence of GO after adjusting the age, gender, smoking, TSHR antibodies, and steroid usage (adjusted odd's ratio (aOR) 1.182, 95% confidence interval (95% CI), 1.003-1.393, p = 0.046; aOR 1.165, 95% CI, 1.001-1.355, p = 0.048; and aOR 1.985, 95% CI, 1.046-3.764, p = 0.036, respectively). In addition, BMI, fasting plasma glucose, fasting plasma insulin, HOMA-IR, and hs-CRP levels were positively correlated with the severity of GO. Conclusions: The findings of this study suggest that obesity-related factors, especially fasting plasma insulin and HOMA-IR, are related to GO. Our study highlighted the importance of obesity-related factors in GO. Obesity-related factors may cause the development of GO or occur simultaneously with GO.enGraves’ orbitopathy; body mass index; fasting plasma insulin; homeostasis model assessment-estimated insulin resistance[SDGs]SDG3journal article10.3390/medicina58121748365569502-s2.0-85144550572https://api.elsevier.com/content/abstract/scopus_id/85144550572