Uemura H.Ye D.Kanesvaran R.Chiong E.Lojanapiwat B.YEONG-SHIAU PURawal S.K.Abdul Razack A.H.Zeng H.Chung B.H.Md Yusoff N.A.Ohyama C.Kim C.S.Leewansangtong S.Tsai Y.-S.Liu Y.Liu W.van Kooten Losio M.Asinas-Tan M.2021-02-022021-02-0220201464-4096https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078843339&doi=10.1111%2fbju.14980&partnerID=40&md5=431552347b7ba4dd7e89bdf36903a0c8https://scholars.lib.ntu.edu.tw/handle/123456789/544297Objectives: To document the management of advanced prostate cancer including diagnosis, prognosis, treatment, and care, in real-world practice in Asia using the United in Fight against prOstate cancer (UFO) registry. Patients and Methods: We established a multi-national, longitudinal, observational registry of patients with prostate cancer presenting to participating tertiary care hospitals in eight Asian countries. A total of 3636 eligible patients with existing or newly diagnosed high-risk localised prostate cancer (HRL), non-metastatic biochemically recurrent prostate cancer (M0), or metastatic prostate cancer (M1), were consecutively enrolled and are being followed-up for 5?years. Patient history, demographic and disease characteristics, treatment and treatment decisions, were collected at first prostate cancer diagnosis and at enrolment. Patient-reported quality of life was prospectively assessed using the European Quality of Life-five Dimensions, five Levels (EQ-5D-5L) and Functional Assessment of Cancer Therapy for Prostate Cancer questionnaires. In the present study, we report the first interim analysis of 2063 patients enrolled from study start (15 September 2015) until 18 May 2017. Results: Of the 2063 enrolled patients, 357 (17%), 378 (19%), and 1328 (64%) had HRL, M0 or M1 prostate cancer, respectively. The mean age at first diagnosis was similar in each group, 56% of all patients had extracapsular extension of their tumour, 28% had regional lymph node metastasis, and 53% had distant metastases. At enrolment, 62% of patients had at least one co-morbidity (mainly cardiovascular disease or diabetes), 91.8% of M1 patients had an Eastern Cooperative Oncology Group performance score of <2 and the mean EQ-5D-5L visual analogue score was 74.6–79.6 across cohorts. Treatment of M1 patients was primarily with combined androgen blockade (58%) or androgen-deprivation therapy (either orchidectomy or luteinising hormone-releasing hormone analogues) (32%). Decisions to start therapy were mainly driven by treatment guidelines and disease progression. Decision to discontinue therapy was most often due to disease progression (hormonal drug therapy) or completion of therapy (chemotherapy). Conclusion: In the UFO registry of advanced prostate cancer in Asia, regional differences exist in prostate cancer treatment patterns that will be explored more deeply during the follow-up period; prospective follow-up is ongoing. The UFO registry will provide valuable descriptive data on current disease characteristics and treatment landscape amongst patients with prostate cancer in Asia. ? 2019 The Authors BJU International Published by John Wiley & Sons Ltd on behalf of BJU International#PCSM; #ProstateCancer; Asia; epidemiology; observational study; prostate cancer; quality of life; registry[SDGs]SDG3abiraterone acetate; bicalutamide; buserelin; cabazitaxel; cyproterone; degarelix; denosumab; docetaxel; enzalutamide; flutamide; gonadorelin derivative; goserelin; leuprorelin; nilutamide; platinum complex; prednisolone; prednisone; prostate specific antigen; radium chloride ra 223; triptorelin; zoledronic acid; adult; Article; Asia; biochemical recurrence; bone metastasis; brachytherapy; cancer prognosis; cancer radiotherapy; cancer registry; cardiovascular disease; China; clinical feature; clinical practice; cohort analysis; comorbidity; conformal radiotherapy; demography; diabetes mellitus; diagnostic procedure; distant metastasis; European Quality of Life 5 Dimensions 5 Level questionnaire; external beam radiotherapy; follow up; Functional Assessment of Cancer Therapy Prostate; health status; human; India; Japan; longitudinal study; lymph node metastasis; major clinical study; Malaysia; male; medical decision making; medical history; metastasis potential; observational study; orchiectomy; patient care; priority journal; prostate cancer; prostatectomy; quality of life; Singapore; South Korea; stereotactic radiosurgery; Taiwan; tertiary care center; Thailand; tumor localization; visual analog scale; aged; clinical trial; metastasis; middle aged; multicenter study; prospective study; prostate tumor; register; treatment outcome; tumor recurrence; Aged; Asia; Cohort Studies; Humans; Longitudinal Studies; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Prospective Studies; Prostatic Neoplasms; Registries; Treatment Outcomejournal article10.1111/bju.14980318689972-s2.0-85078843339