Lin, H-F.H-F.LinChou, C-C.C-C.ChouCheng, H-M.H-M.ChengTanaka, H.H.Tanaka2019-12-312019-12-312017https://scholars.lib.ntu.edu.tw/handle/123456789/444208Objectives: Eccentric exercise induces muscle stiffening and soreness as well as unfavorable changes in macrovascular function. We tested the hypothesis that systemic eccentric exercise could evoke greater arterial stiffening than local eccentric resistance exercise. Design and Intervention: Twenty healthy young men were randomly assigned into either the downhill running (DR) and the eccentric resistance exercise (RE) group followed by a crossover design with an exercise and sham control trial. Main Outcome Measures: Carotid-femoral pulse wave velocity (cfPWV), central hemodynamic measures, and biomarkers were obtained. Results: Muscle soreness and plasma creatine kinase concentrations increased similarly after exercise in both groups. The cfPWV increased significantly at 48 hours post-exercise in both groups and remained elevated at 72 hours in DR. C-reactive protein (CRP) was elevated at 24 and 48 hours in DR, and 48 hours in RE. The increases in cfPWV were associated with the corresponding elevations in CRP in DR (r = 0.70, P < 0.05). There were no changes in arterial wave reflection measures. Conclusions: Both systemic and localized eccentric exercise modes induced delayed onset vascular stiffening with more prolonged changes observed in downhill running. The effect on arterial stiffening was associated, at least in part, with systemic inflammatory responses. Copyright ? 2016 Wolters Kluwer Health, Inc. All rights reserved.arterial stiffness; delayed onset muscle soreness; inflammation; muscle damage[SDGs]SDG3biological marker; C reactive protein; creatine kinase; biological marker; creatine kinase; adult; arterial stiffness; Article; carotid artery pulse; controlled study; creatine kinase blood level; crossover procedure; downhill running; eccentric muscle contraction; femoral artery flow; hemodynamic parameters; human; human experiment; male; motor evoked potential; muscle strength; myalgia; normal human; physical activity; priority journal; pulse wave; quadriceps femoris muscle; resistance training; running; sham procedure; young adult; blood; hemodynamics; pathophysiology; physiology; randomized controlled trial; running; skeletal muscle; Biomarkers; Creatine Kinase; Cross-Over Studies; Hemodynamics; Humans; Male; Muscle, Skeletal; Myalgia; Pulse Wave Analysis; Resistance Training; Running; Vascular Stiffness; Young Adultjournal article10.1097/JSM.0000000000000348