Chang, Yi-YaoYi-YaoChangLee, Hsiu-HaoHsiu-HaoLeeCHI-SHENG HUNGWu, Xue-MingXue-MingWuJEN-KUANG LEEWang, Shuo-MengShuo-MengWangMIN-TSUN LIAOYING-HSIEN CHENVIN-CENT WUKWAN-DUN WUYEN-HUNG LINYI-LWUN HOChang, Hung-WeiHung-WeiChangLIAN-YU LINHu, Fu-ChangFu-ChangHuKAO-LANG LIUHuang, Kuo-HowKuo-HowHuangYUNG-MING CHENKuo, Chin-ChiChin-ChiKuoChueh, Shih-ChiehShih-ChiehChuehCHING-CHU LUChang, Fang-ChiFang-ChiChangLiao, Shih-ChengShih-ChengLiaoRUOH-FANG YENWEI-CHOU LINHsieh, Bor-SenBor-SenHsieh2023-03-092023-03-092014-090009-9120https://scholars.lib.ntu.edu.tw/handle/123456789/629083Objective: To investigate the association between aldosterone and cardiac diastolic dysfunction. Design and methods: We prospectively enrolled 20 patients with primary aldosteronism (PA) and 22 patients with essential hypertension (EH). Plasma aldosterone concentration, plasma renin activity, and 24-h urine aldosterone level were measured. Echocardiography, including tissue Doppler image recordings, was performed. Results: PA patients had a significantly higher left ventricular (LV) mass index and worse LV diastolic function than those in EH patients. Among various measures of aldosterone, log-transformed 24-h urine aldosterone level had the most consistent correlation with diastolic function. Conclusions: Aldosterone is strongly associated with LV diastolic dysfunction. Twenty-four hour urine aldosterone is a good indicator to evaluate the impact of aldosterone on LV diastolic function.enDiastolic dysfunction; Primary aldosteronism; Urine aldosteronejournal article10.1016/j.clinbiochem.2014.05.062248929012-s2.0-84929128526WOS:000341329000031