Tsou T.-P.Chen W.-C.Huang A.S.-E.SHAN-CHWEN CHANGSu C.-P.Lee P.-H.Chan P.-C.Wu H.-H.Huang S.-T.Su W.-J.Su Y.-S.Wei H.-Y.Chen M.-Y.Wu P.-Y.Wang K.-C.Tsai H.-T.Lee H.-C.Hung M.-N.the Taiwan COVID-19 Outbreak Investigation Team2020-12-302020-12-3020200929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-85088558085&doi=10.1016%2fj.jfma.2020.07.015&partnerID=40&md5=518f5be93cc211f7ba0ae4d27723caa7https://scholars.lib.ntu.edu.tw/handle/123456789/536143Purpose: To describe the epidemiology and outcome of the first 100 COVID-19 cases in Taiwan. Methods: We included the first 100 patients with laboratory-confirmed SARS-CoV-2 infection in Taiwan. Demographic, clinical, epidemiological and laboratory data were extracted from outbreak investigation reports and medical records. Results: Illness onset of the 100 patients was during January 11 to March 16, 2020. Twenty-nine (29%) had at least one underlying condition and ten (10%) were asymptomatic. Seventy-one were imported, including four clusters. Twenty-nine were locally-acquired, including four clusters. The median days from onset to report was longer in locally-acquired cases (10 vs 3 days). Three patients died (case fatality rate 3%) and all of them had underlying conditions. As of May 13, 2020, 93 had been discharged in stable condition; the median hospital stay was 30 days (range, 10–79 days). Conclusion: The first 100 cases of COVID-19 in Taiwan showed the persistent threat of imported cases from different countries. Even though sporadic locally-acquired disease has been identified, through contact investigation, isolation, quarantine and implementation of social distancing measures, the epidemic is contained to a manageable level with minimal local transmission. ? 2020COVID-19; Epidemiology; SARS-CoV-2; Taiwan[SDGs]SDG3azithromycin; C reactive protein; D dimer; hydroxychloroquine; lopinavir plus ritonavir; adolescent; adult; adult respiratory distress syndrome; aged; anosmia; Article; artificial ventilation; asymptomatic infection; cardiovascular disease; case fatality rate; child; chronic lung disease; clinical feature; combination drug therapy; contact examination; controlled study; coronavirus disease 2019; coughing; diabetes mellitus; diarrhea; dysgeusia; epidemic; extracorporeal oxygenation; female; fever; hospital discharge; hospitalization; human; hypertension; hyposmia; infection control; influenza; leukocyte count; major clinical study; male; nausea and vomiting; pneumonia; septic shock; Severe acute respiratory syndrome coronavirus 2; sore throat; Taiwanjournal article10.1016/j.jfma.2020.07.015