Lai P.-S.Pai C.-L.Hsu C.-Y.MING-JIUM SHIEH2020-02-272020-02-272010https://www.scopus.com/inward/record.uri?eid=2-s2.0-78049449313&partnerID=40&md5=a62b7cf0d2833f84642d1a4ebb47a57ehttps://scholars.lib.ntu.edu.tw/handle/123456789/465779Targetable drug delivery system is a promising tool for cancer treatments. Herein we report a novel strategy of using G-quadruplex AS1411 aptamer-conjugated polyethylene-polylactide formed polymeric micelles (apt-PEG-PLA-PM) as a drug carrier to target cancer cells for chemotherapy. G-quadruplex AS1411 aptamer is known to target to nucleolin over-expressed in cancer cells. In this study, the effect of AS1411 aptamer-conjugated polymeric micelle for drug delivery via nucleolin-mediated internalization was investigated. Our results showed that the apt-PEG-PLA-PM exhibited higher cytotoxicity in MCF-7 breast cancer cells than in M10 normal epithelium cells. It is suggested that the apt-PEG-PLA-PM was mainly internalized into cells via the specific interaction of AS1411 aptamer with nucleolin on the cell surface and this nucleolin-targetable polymeric micelle can be a potential drug carrier for cancer therapy.AS1411; Cancer therapy; Polymeric micelle[SDGs]SDG3Aptamers; AS1411; Cancer cells; Cancer therapy; Cancer treatment; Cell surfaces; Drug carrier; Drug delivery system; Epithelium cells; G-quadruplexes; MCF-7 breast cancer cells; Novel strategies; Nucleolin; Peg-pla; Poly lactide; Polymeric micelle; Potential drug; Specific interaction; Cell membranes; Chemotherapy; Drug delivery; Drug interactions; Medical nanotechnology; Oncology; Sensors; Micellesconference paper2-s2.0-78049449313