Chao, C.-H.C.-H.ChaoHuang, T.-Z.T.-Z.HuangWu, C.-Y.C.-Y.WuChen, B.-W.B.-W.ChenHuang, C.-Y.C.-Y.HuangHwang, T.-L.T.-L.HwangCHANG-FENG DAISheu, J.-H.J.-H.Sheu2018-09-102018-09-102015http://www.scopus.com/inward/record.url?eid=2-s2.0-84941236837&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/391669Two new pregnane glycosides, hirsutosterosides A and B (1 and 2), as well as two new α-tocopherylhydroquinone glycosides, cladophenol glycosides A and B (3 and 4) were isolated from a soft coral Cladiella hirsuta. In addition, a new steroidal glycoside, lobatasteroside A (5) along with six known steroids (6-11), were discovered from the other soft coral Sinularia nanolobata. Their structures were elucidated by extensive spectroscopic analysis. Cytotoxicities of the isolates against a limited panel of cancer cell lines were reported. The inhibitory activities for superoxide anion generation and elastase release for these compounds were also examined to evaluate the anti-inflammatory potential. ? 2015 The Royal Society of Chemistry.[SDGs]SDG3Cell culture; Oxygen; Spectroscopic analysis; Anti-inflammatories; Cancer cell lines; Elastase; Inhibitory activity; Soft corals; Superoxide anions; Sugarsjournal article10.1039/c5ra13436f2-s2.0-84941236837