Hsiao P.H.Chou Y.H.Tsou Yau K.I.MEI-HWEI CHANG2021-01-042021-01-0419930001-6578https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027688629&partnerID=40&md5=44b2a6541181158c753717cd67605691https://scholars.lib.ntu.edu.tw/handle/123456789/537250From January 1984 to March 1992, there were 19 infants admitted to our hospital with gastrointestinal perforation not associated with necrotizing enterocolitis. Seven patients (37%) were premature. Six patients (32%) had their perforations located in the stomach, 9 (47%) in the small intestine, and 3 (16%) in the colon. The most common clinical presentation was abdominal distention (95%). Pneumoperitoneum was noted only in 12 (63%) patients. About 60% of the patients had the perforation occur before 4 days of age. The predominant cause of perforation was unknown, so called spontaneous perforation (8/19, 42%), followed by ischemia or infarction (5/19, 26%). The overall mortality rate was 32%. The non-survivors had more severe metabolic acidosis than the survivors, but there were no differences in the birthweight and gestational ages of these two groups. Sepsis accounted for 83% of the deaths. Early diagnosis and treatment are the best ways to promote survival.[SDGs]SDG3article; female; human; infant; intestine perforation; male; newborn; pseudomembranous colitis; stomach disease; Enterocolitis, Pseudomembranous; Female; Humans; Infant; Infant, Newborn; Intestinal Perforation; Male; Stomach Diseasesjournal article82965542-s2.0-0027688629