2012-12-012024-05-18https://scholars.lib.ntu.edu.tw/handle/123456789/699558摘要：對於人類注意力與工作記憶的探討，分別是心理學與認知神經科學領域長久以來非常重要的研究議題。近年來，由於腦功能造影技術的快速發展，許多新的研究證據顯示，注意力與工作記憶歷程事實上涉及了許多重疊的神經機制運作；然而，研究者卻仍然不了解這兩個重要的認知歷程是如何進行互動。在這個研究計畫裡，我假設由上而下調控的機制在這兩個認知歷程上扮演了一個關鍵且共同的角色，即採取一種偏誤競爭的模式，以選擇與我們所從事作業目的或當下行為期望相符合的刺激訊息。因此，我計畫探討由上而下調控的對工作記憶中訊息登錄(第一年：系列實驗一)與訊息維持階段(第二年：系列實驗二)的調節與影響。更重要的是，透過這兩個系列實驗，我將檢驗這個對工作記憶訊息表徵由上而下調控的機制，與注意力由上而下調控的歷程，涉及了相類似的神經機制運作。為了檢驗這些假設，我將彙整行為研究測量、腦電波分析與事件相關電位，以及功能性磁振造影等腦功能測量方法，以建立行為表現與大腦神經機制間的相關。更重要的是，我希望藉此研究釐清由上而下調控機制，是如何根據作業目標與行為要求，在知覺處理、工作記憶訊息登錄，以及表徵訊息維持等歷程上，進行連續性與動態性的調節，最後使人們能有效率的選擇與維持對我們有意義的資訊，並成功完成目標作業。<br> Abstract: Attention and working memory are recently viewed as overlapping mechanisms. However, how these two mechanisms interact remains unclear to date. In this research proposal, I hypothesize that top-down modulatory mechanisms serve as a common architecture for attention and working memory. I will test whether and how top-down modulatory mechanisms can influence working memory encoding (Experiment series 1, first year) and maintenance (Experiment series 2, second year) in a biased competitive fashion. I will also show that the underlying neural processes of top-down modulation of working memory are analogues to those of perceptual processing. More importantly, I will converge multiple cognitive and brain imaging methods including behavioural measures, electroencephalography, event-related potentials and event-related functional magnetic resonance imaging to establish the link between brain and behaviour. This research proposal will reinforce the notion of working memory representations that can be modulated dynamically and continuously by top-down modulation according to our task goals and behavioural expectations, biasing competition in favour of task-relevant information.注意力工作記憶由上而下調控腦電波事件相關電位功能性磁振造影Attentionworking memorytop-down modulationelectroencephalographyevent-related potentialsfunctional magnetic resonance imaging